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DOI | 10.1126/science.aak9867 |
Crystal structure of the overlapping dinucleosome composed of hexasome and octasome | |
Kato, Daiki1; Osakabe, Akihisa1; Arimura, Yasuhiro1; Mizukami, Yuka1; Horikoshi, Naoki1; Saikusa, Kazumi2,3; Akashi, Satoko3; Nishimura, Yoshifumi3; Park, Sam-Yong3; Nogami, Jumpei4; Maehara, Kazumitsu4; Ohkawa, Yasuyuki4; Matsumoto, Atsushi5; Kono, Hidetoshi5; Inoue, Rintaro6; Sugiyama, Masaaki6; Kurumizaka, Hitoshi1,7 | |
2017-04-14 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6334页码:205-208 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | Nucleosomes are dynamic entities that are repositioned along DNA by chromatin remodeling processes. A nucleosome repositioned by the switch-sucrose nonfermentable (SWI/SNF) remodeler collides with a neighbor and forms the intermediate" overlapping dinucleosome." Here, we report the crystal structure of the overlapping dinucleosome, in which two nucleosomes are associated, at 3.14-angstrom resolution. In the overlapping dinucleosome structure, the unusual "hexasome" nucleosome, composed of the histone hexamer lacking one H2A-H2B dimer from the conventional histone octamer, contacts the canonical "octasome" nucleosome, and they intimately associate. Consequently, about 250 base pairs of DNA are left-handedly wrapped in three turns, without a linker DNA segment between the hexasome and octasome moieties. The overlapping dinucleosome structure may provide important information to understand how nucleosome repositioning occurs during the chromatin remodeling process. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399013800041 |
WOS关键词 | NUCLEOSOME CORE PARTICLE ; H2A/H2B DIMER ; DNA ; MECHANISMS ; RESOLUTION ; HISTONES ; REVEALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195816 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Waseda Univ, Grad Sch Adv Sci & Engn, Struct Biol Lab, Shinjuku Ku, 2-2 Wakamatsu Cho, Tokyo 1628480, Japan; 2.Hiroshima Univ, Grad Sch Sci, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 7398526, Japan; 3.Yokohama City Univ, Grad Sch Med Life Sci, Tsurumi Ku, 1-7-29 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan; 4.Kyushu Univ, Med Inst Bioregulat, Div Transcript, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan; 5.Natl Inst Quantum & Radiol Sci & Technol, Kizu, Kyoto 6190215, Japan; 6.Kyoto Univ, Inst Res Reactor, Osaka 5900494, Japan; 7.Waseda Univ, Inst Med Oriented Struct Biol, Shinjuku Ku, 2-2 Wakamatsu Cho, Tokyo 1628480, Japan |
推荐引用方式 GB/T 7714 | Kato, Daiki,Osakabe, Akihisa,Arimura, Yasuhiro,et al. Crystal structure of the overlapping dinucleosome composed of hexasome and octasome[J]. SCIENCE,2017,356(6334):205-208. |
APA | Kato, Daiki.,Osakabe, Akihisa.,Arimura, Yasuhiro.,Mizukami, Yuka.,Horikoshi, Naoki.,...&Kurumizaka, Hitoshi.(2017).Crystal structure of the overlapping dinucleosome composed of hexasome and octasome.SCIENCE,356(6334),205-208. |
MLA | Kato, Daiki,et al."Crystal structure of the overlapping dinucleosome composed of hexasome and octasome".SCIENCE 356.6334(2017):205-208. |
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