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DOI | 10.1126/science.aal4365 |
Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity | |
Bardina, Susana V.1; Bunduc, Paul1; Tripathi, Shashank1,2; Duehr, James1; Frere, Justin J.1; Brown, Julia A.1; Nachbagauer, Raffael1; Foster, Gregory A.3; Krysztof, David3; Tortorella, Domenico1; Stramer, Susan L.; Garcia-Sastre, Adolfo1,2,4; Krammer, Florian1; Lim, Jean K.1 | |
2017-04-14 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6334页码:175-180 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Zika virus (ZIKV) is spreading rapidly into regions around the world where other flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV), are endemic. Antibody-dependent enhancement has been implicated in more severe forms of flavivirus disease, but whether this also applies to ZIKV infection is unclear. Using convalescent plasma from DENV- and WNV-infected individuals, we found substantial enhancement of ZIKV infection in vitro that was mediated through immunoglobulin G engagement of Fcg receptors. Administration of DENV- or WNV-convalescent plasma into ZIKV-susceptible mice resulted in increased morbidity-including fever, viremia, and viral loads in spinal cord and testes-and increased mortality. Antibody-dependent enhancement may explain the severe disease manifestations associated with recent ZIKV outbreaks and highlights the need to exert great caution when designing flavivirus vaccines. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399013800033 |
WOS关键词 | WEST-NILE-VIRUS ; ANTIBODY-DEPENDENT ENHANCEMENT ; DENGUE HEMORRHAGIC-FEVER ; CROSS-REACTIVITY ; INFECTION ; FC ; FLAVIVIRUSES ; EPIDEMIOLOGY ; ACTIVATION ; CORRELATE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195809 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA; 2.Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA; 3.Amer Red Cross, Gaithersburg, MD 20877 USA; 4.Icahn Sch Med Mt Sinai, Div Infect Dis, Dept Med, New York, NY 10029 USA |
推荐引用方式 GB/T 7714 | Bardina, Susana V.,Bunduc, Paul,Tripathi, Shashank,et al. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity[J]. SCIENCE,2017,356(6334):175-180. |
APA | Bardina, Susana V..,Bunduc, Paul.,Tripathi, Shashank.,Duehr, James.,Frere, Justin J..,...&Lim, Jean K..(2017).Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity.SCIENCE,356(6334),175-180. |
MLA | Bardina, Susana V.,et al."Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity".SCIENCE 356.6334(2017):175-180. |
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