Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

doi:10.1126/science.aah5298

GSTDTAP > 地球科学

DOI	10.1126/science.aah5298
	Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease
	Bouziat, Romain 1,2; Hinterleitner, Reinhard 1,2; Brown, Judy J.3,4; Stencel-Baerenwald, Jennifer E.3,4; Ikizler, Mine 4,5; Mayassi, Toufic 1,2; Meisel, Marlies 1,2; Kim, Sangman M.1,2; Discepolo, Valentina 1,6; Pruijssers, Andrea J.4,5; Ernest, Jordan D.1,2; Iskarpatyoti, Jason A.4,5; Costes, Lea M. M.1,7; Lawrence, Ian 1,2; Palanski, Brad A.8; Varma, Mukund 9,10,11,12,13; Zurenski, Matthew A.1,2; Khomandiak, Solomiia 4,5; McAllister, Nicole 3,4; Aravamudhan, Pavithra 4,5; Boehme, Karl W.4,5; Hu, Fengling 1; Samsom, Janneke N.7; Reinecker, Hans-Christian 9,10,11; Kupfer, Sonia S.1; Guandalini, Stefano 14,15; Semrad, Carol E.1,14; Abadie, Valerie 16,17; Khosla, Chaitan 18,19; Barreiro, Luis B.20; Xavier, Ramnik J.9,10,11,11,12,13,21; Ng, Aylwin 9,10,11,12,13; Dermody, Terence S.3,4,5,22,23; Jabri, Bana 1,2,14,15,24
	2017-04-07
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	356 期号:6333 页码:44-+
文章类型	Article
语种	英语
国家	USA; Italy; Netherlands; Canada
英文摘要	Viral infections have been proposed to elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this hypothesis and gain insights into mechanisms underlying virus-induced loss of tolerance to dietary antigens, we developed a viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes. Reovirus is an avirulent pathogen that elicits protective immunity, but we discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen. Initiation of TH1 immunity to dietary antigen was dependent on interferon regulatory factor 1 and dissociated from suppression of pTreg conversion, which was mediated by type-1 interferon. Last, our study in humans supports a role for infection with reovirus, a seemingly innocuous virus, in triggering the development of CeD.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000398689100033
WOS关键词	REGULATORY FACTOR-I ; CLASSICAL DENDRITIC CELLS ; IMMUNE-RESPONSES ; NATURAL-HISTORY ; ORAL TOLERANCE ; T-CELLS ; CHILDREN ; MICE ; EXPRESSION ; TISSUE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/195777
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Chicago, Dept Med, Chicago, IL USA; 2.Univ Chicago, Comm Immunol, Chicago, IL USA; 3.Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN USA; 4.Vanderbilt Univ, Med Ctr, Elizabeth B Lamb Ctr Pediat Res, Nashville, TN USA; 5.Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN USA; 6.Univ Naples Federico II, CeInGe Biotecnol Avanzate, Dept Translat Med Sci, Sect Pediat, Naples, Italy; 7.Erasmus Univ, Rotterdam Sophia Childrens Hosp, Med Ctr, Div Gastroenterol & Nutr,Lab Pediat, Rotterdam, Netherlands; 8.Stanford Univ, Dept Chem, Stanford, CA USA; 9.Massachusetts Gen Hosp, Dept Med, Div Gastroenterol, Gastrointestinal Unit, Boston, MA USA; 10.Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA USA; 11.Harvard Med Sch, Boston, MA USA; 12.Harvard Univ, Cambridge, MA 02138 USA; 13.MIT, Broad Inst, Cambridge, MA 02138 USA; 14.Univ Chicago, Celiac Dis Ctr, Chicago, IL USA; 15.Univ Chicago, Dept Pediat, Sect Gastroenterol Hepatol & Nutr, Chicago, IL USA; 16.Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada; 17.Ctr Hosp Univ CHU, St Justine Res Ctr, Montreal, PQ, Canada; 18.Stanford Univ, Dept Chem Engn, Stanford, CA USA; 19.Stanford Univ, Stanford ChEM H, Stanford, CA USA; 20.CHU St Justine Res Ctr, Dept Genet, Montreal, PQ, Canada; 21.Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA USA; 22.Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA USA; 23.Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA; 24.Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
推荐引用方式 GB/T 7714	Bouziat, Romain,Hinterleitner, Reinhard,Brown, Judy J.,et al. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease[J]. SCIENCE,2017,356(6333):44-+.
APA	Bouziat, Romain.,Hinterleitner, Reinhard.,Brown, Judy J..,Stencel-Baerenwald, Jennifer E..,Ikizler, Mine.,...&Jabri, Bana.(2017).Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.SCIENCE,356(6333),44-+.
MLA	Bouziat, Romain,et al."Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease".SCIENCE 356.6333(2017):44-+.