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DOI | 10.1126/science.aam6808 |
Engrams and circuits crucial for systems consolidation of a memory | |
Kitamura, Takashi1,2; Ogawa, Sachie K.1,2; Roy, Dheeraj S.1,2; Okuyama, Teruhiro1,2; Morrissey, Mark D.1,2; Smith, Lillian M.1,2; Redondo, Roger L.1,2,3; Tonegawa, Susumu1,2,3 | |
2017-04-07 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6333页码:73-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown. We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhinal cortex network and the basolateral amygdala. After their generation, the prefrontal engram cells, with support from hippocampal memory engram cells, became functionally mature with time. Whereas hippocampal engram cells gradually became silent with time, engram cells in the basolateral amygdala, which were necessary for fear memory, were maintained. Our data provide new insights into the functional reorganization of engrams and circuits underlying systems consolidation of memory. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000398689100040 |
WOS关键词 | COMPLEMENTARY LEARNING-SYSTEMS ; RETROGRADE-AMNESIA ; FEAR ; CELLS ; HIPPOCAMPUS ; REACTIVATION ; RETRIEVAL ; ENSEMBLES ; NEOCORTEX ; ABSENCE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195761 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MIT, RIKEN MIT Ctr Neural Circuit Genet, Picower Inst Learning & Memory, Dept Biol, Cambridge, MA 02139 USA; 2.MIT, RIKEN MIT Ctr Neural Circuit Genet, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA; 3.MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Kitamura, Takashi,Ogawa, Sachie K.,Roy, Dheeraj S.,et al. Engrams and circuits crucial for systems consolidation of a memory[J]. SCIENCE,2017,356(6333):73-+. |
APA | Kitamura, Takashi.,Ogawa, Sachie K..,Roy, Dheeraj S..,Okuyama, Teruhiro.,Morrissey, Mark D..,...&Tonegawa, Susumu.(2017).Engrams and circuits crucial for systems consolidation of a memory.SCIENCE,356(6333),73-+. |
MLA | Kitamura, Takashi,et al."Engrams and circuits crucial for systems consolidation of a memory".SCIENCE 356.6333(2017):73-+. |
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