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DOI | 10.1126/science.aaf0683 |
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent | |
Kamphorst, Alice O.1; Wieland, Andreas1; Nasti, Tahseen1; Yang, Shu1,2,13; Zhang, Ruan3,4; Barber, Daniel L.1,5; Konieczny, Bogumila T.1; Daugherty, Candace Z.1; Koenig, Lydia6; Yu, Ke6; Sica, Gabriel L.7; Sharpe, Arlene H.8,9,10; Freeman, Gordon J.11; Blazar, Bruce R.12; Turka, Laurence A.3,4; Owonikoko, Taofeek K.6; Pillai, Rathi N.6; Ramalingam, Suresh S.6; Araki, Koichi1; Ahmed, Rafi1 | |
2017-03-31 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6332页码:1423-1427 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Programmed cell death-1 (PD-1)-targeted therapies enhance T cell responses and show efficacy in multiple cancers, but the role of costimulatory molecules in this T cell rescue remains elusive. Here, we demonstrate that the CD28/B7 costimulatory pathway is essential for effective PD-1 therapy during chronic viral infection. Conditional gene deletion showed a cell-intrinsic requirement of CD28 for CD8 T cell proliferation after PD-1 blockade. B7-costimulation was also necessary for effective PD-1 therapy in tumor-bearing mice. In addition, we found that CD8 T cells proliferating in blood after PD-1 therapy of lung cancer patients were predominantly CD28-positive. Taken together, these data demonstrate CD28-costimulation requirement for CD8 T cell rescue and suggest an important role for the CD28/B7 pathway in PD-1 therapy of cancer patients. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397809500043 |
WOS关键词 | CHRONIC VIRAL-INFECTION ; RESPONSES ; IMMUNITY ; CANCER ; PD-1 ; COSTIMULATION ; BLOCKADE ; EFFECTOR ; MEMORY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195737 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Emory Univ, Sch Med, Emory Vaccine Ctr, Dept Microbiol & Immunol, Atlanta, GA 30322 USA; 2.Cent S Univ, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China; 3.Massachusetts Gen Hosp, Dept Surg, Boston, MA 02144 USA; 4.Harvard Med Sch, Boston, MA 02144 USA; 5.NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA; 6.Emory Univ, Sch Med, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA; 7.Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA; 8.Harvard Med Sch, Dept Microbiol & Immunol, Boston, MA 02115 USA; 9.Harvard Med Sch, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA; 10.Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA; 11.Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA; 12.Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA; 13.Tianjin Med Univ, Gen Hosp, Dept Neurol, Tianjin 300052, Peoples R China |
推荐引用方式 GB/T 7714 | Kamphorst, Alice O.,Wieland, Andreas,Nasti, Tahseen,et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent[J]. SCIENCE,2017,355(6332):1423-1427. |
APA | Kamphorst, Alice O..,Wieland, Andreas.,Nasti, Tahseen.,Yang, Shu.,Zhang, Ruan.,...&Ahmed, Rafi.(2017).Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.SCIENCE,355(6332),1423-1427. |
MLA | Kamphorst, Alice O.,et al."Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent".SCIENCE 355.6332(2017):1423-1427. |
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