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DOI | 10.1126/science.aal2913 |
Gene bivalency at Polycomb domains regulates cranial neural crest positional identity | |
Minoux, Maryline1,2; Holwerda, Sjoerd1; Vitobello, Antonio1; Kitazawa, Taro1; Kohler, Hubertus1; Stadler, Michael B.1,3; Rijli, Filippo M.1,4 | |
2017-03-31 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6332 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; France |
英文摘要 | The cranial neural crest cells are multipotent cells that provide head skeletogenic mesenchyme and are crucial for craniofacial patterning. We analyzed the chromatin landscapes of mouse cranial neural crest subpopulations in vivo. Early postmigratory subpopulations contributing to distinct mouse craniofacial structures displayed similar chromatin accessibility patterns yet differed transcriptionally. Accessible promoters and enhancers of differentially silenced genes carried H3K27me3/H3K4me2 bivalent chromatin marks embedded in large enhancer of zeste homolog 2-dependent Polycomb domains, indicating transcriptional poising. These postmigratory bivalent chromatin regions were already present in premigratory progenitors. At Polycomb domains, H3K27me3 antagonized H3K4me2 deposition, which was restricted to accessible sites. Thus, bivalent Polycomb domains provide a chromatin template for the regulation of cranial neural crest cell positional identity in vivo, contributing insights into the epigenetic regulation of face morphogenesis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397809500033 |
WOS关键词 | HOMEOTIC TRANSFORMATION ; CELL-MIGRATION ; HOXA2 ; ACTIVATION ; ENHANCER ; SPECIFICATION ; MUTATIONS ; SKELETAL ; PLURIPOTENT ; METHYLATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195720 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Friedrich Miescher Inst Biomed Res, Maulbeerstr 66, CH-4051 Basel, Switzerland; 2.Univ Strasbourg, Fac Chirurg Dentaire, INSERM, UMR 1121, 8 Rue St Elisabeth, F-67000 Strasbourg, France; 3.Swiss Inst Bioinformat, Maulbeerstr 66, CH-4051 Basel, Switzerland; 4.Univ Basel, CH-4003 Basel, Switzerland |
推荐引用方式 GB/T 7714 | Minoux, Maryline,Holwerda, Sjoerd,Vitobello, Antonio,et al. Gene bivalency at Polycomb domains regulates cranial neural crest positional identity[J]. SCIENCE,2017,355(6332). |
APA | Minoux, Maryline.,Holwerda, Sjoerd.,Vitobello, Antonio.,Kitazawa, Taro.,Kohler, Hubertus.,...&Rijli, Filippo M..(2017).Gene bivalency at Polycomb domains regulates cranial neural crest positional identity.SCIENCE,355(6332). |
MLA | Minoux, Maryline,et al."Gene bivalency at Polycomb domains regulates cranial neural crest positional identity".SCIENCE 355.6332(2017). |
条目包含的文件 | 条目无相关文件。 |
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