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DOI | 10.1126/science.aad8242 |
AGING A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging | |
Li, Jun1; Bonkowski, Michael S.1; Moniot, Sebastien2; Zhang, Dapeng3; Hubbard, Basil P.1,8; Ling, Alvin J. Y.1; Rajman, Luis A.1; Qin, Bo4; Lou, Zhenkun4; Gorbunova, Vera5; Aravind, L.; Steegborn, Clemens2; Sinclair, David A.1,6 | |
2017-03-24 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6331页码:1312-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany; Australia; Canada |
英文摘要 | DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD(+) (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD(+) to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate-ribose) polymerase], a critical DNA repair protein. As mice age and NAD(+) concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a process rapidly reversed by restoring the abundance of NAD(+). Thus, NAD(+) directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397082900039 |
WOS关键词 | NICOTINAMIDE MONONUCLEOTIDE ; DNA-REPAIR ; CELL ; MECHANISM ; SIRTUINS ; PATHWAY ; DISEASE ; SIRT1 ; DBC1 ; LIFE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195693 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Med Sch, Paul F Glenn Ctr Biol Aging, Dept Genet, Boston, MA 02115 USA; 2.Univ Bayreuth, Dept Biochem, D-95440 Bayreuth, Germany; 3.Natl Inst Hlth, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA; 4.Dept Oncol, Div Oncol Res, Mayo Clin, 200 Ist St SW, Rochester, MN 55905 USA; 5.Div Biol, 434 Hutchinson Hall,River Campus, Rochester, NY 14627 USA; 6.Univ New South Wales, Sch Med Sci, Dept Pharmacol, Sydney, NSW 2052, Australia; 7.St Louis Univ, Dept Biol, St Louis, MO 63103 USA; 8.Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada |
推荐引用方式 GB/T 7714 | Li, Jun,Bonkowski, Michael S.,Moniot, Sebastien,et al. AGING A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging[J]. SCIENCE,2017,355(6331):1312-+. |
APA | Li, Jun.,Bonkowski, Michael S..,Moniot, Sebastien.,Zhang, Dapeng.,Hubbard, Basil P..,...&Sinclair, David A..(2017).AGING A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging.SCIENCE,355(6331),1312-+. |
MLA | Li, Jun,et al."AGING A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging".SCIENCE 355.6331(2017):1312-+. |
条目包含的文件 | 条目无相关文件。 |
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