Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaf9011 |
CANCER ETIOLOGY Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention | |
Tomasetti, Cristian1,2; Li, Lu2; Vogelstein, Bert3 | |
2017-03-24 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6331页码:1330-1334 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries, regardless of their environment. The major role of R mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers. All of these results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment. Moreover, they accentuate the importance of early detection and intervention to reduce deaths from the many cancers arising from unavoidable R mutations. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397082900043 |
WOS关键词 | RISK-FACTORS ; TISSUES ; TRENDS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195692 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Johns Hopkins Univ Sch Med, Div Biostatist & Bioinformat, Dept Oncol, Sidney Kimmel Canc Ctr, Baltimore, MD 21205 USA; 2.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostatist, 615 N Wolfe St, Baltimore, MD 21205 USA; 3.Ludwig Ctr & Howard Hughes Med Inst, Johns Hopkins Kimmel Canc Ctr, 1650 Orleans St, Baltimore, MD 21205 USA |
推荐引用方式 GB/T 7714 | Tomasetti, Cristian,Li, Lu,Vogelstein, Bert. CANCER ETIOLOGY Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention[J]. SCIENCE,2017,355(6331):1330-1334. |
APA | Tomasetti, Cristian,Li, Lu,&Vogelstein, Bert.(2017).CANCER ETIOLOGY Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.SCIENCE,355(6331),1330-1334. |
MLA | Tomasetti, Cristian,et al."CANCER ETIOLOGY Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention".SCIENCE 355.6331(2017):1330-1334. |
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