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DOI | 10.1126/science.aam7340 |
Waste disposal-An attractive strategy for cancer therapy | |
Salami, Jemilat1; Crews, Craig M.1,2,3 | |
2017-03-17 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6330页码:1163-1167 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | Targeted therapies for cancer are typically small molecules or monoclonal antibodies that act by inhibiting the activity of specific proteins that drive tumor growth. Although many of these drugs are effective in cancer patients, the response is often not durable because tumor cells develop resistance to the drugs. Another limitation of this strategy is that not all oncogenic driver proteins are "druggable" enzymes or receptors with activities that can be inhibited. Here we describe an alternative approach to targeted therapy that is based on co-opting the cellular quality-control machinery-the ubiquitin-proteasome system-to remove specific cancer-causing proteins from the cell. We first discuss examples of existing cancer drugs that work by degrading specific proteins and then review recent progress in the rational design and preclinical testing of small molecules that induce selective degradation of specific target proteins. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396351200034 |
WOS关键词 | RESISTANT PROSTATE-CANCER ; BET BROMODOMAIN PROTEIN ; MULTIPLE-MYELOMA CELLS ; ANDROGEN RECEPTOR ; BREAST-CANCER ; SELECTIVE DEGRADATION ; MEDIATED DEGRADATION ; SMALL MOLECULES ; TARGET ; UBIQUITINATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195627 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA; 2.Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA; 3.Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA |
推荐引用方式 GB/T 7714 | Salami, Jemilat,Crews, Craig M.. Waste disposal-An attractive strategy for cancer therapy[J]. SCIENCE,2017,355(6330):1163-1167. |
APA | Salami, Jemilat,&Crews, Craig M..(2017).Waste disposal-An attractive strategy for cancer therapy.SCIENCE,355(6330),1163-1167. |
MLA | Salami, Jemilat,et al."Waste disposal-An attractive strategy for cancer therapy".SCIENCE 355.6330(2017):1163-1167. |
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