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DOI | 10.1126/science.aal4326 |
Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution | |
Shen, Huaizong1,2; Zhou, Qiang1,2,3,4; Pan, Xiaojing1,2; Li, Zhangqiang1,2,3,4; Wu, Jianping1,2,3,4; Yan, Nieng1,2,3,4 | |
2017-03-03 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6328 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | Voltage-gated sodium (Nav) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of channelopathies and are targeted by multiple pharmaceutical drugs and natural toxins. Here, we report the cryogenic electron microscopy structure of a putative Nav channel from American cockroach (designated NavPaS) at 3.8 angstrom resolution. The voltage-sensing domains (VSDs) of the four repeats exhibit distinct conformations. The entrance to the asymmetric selectivity filter vestibule is guarded by heavily glycosylated and disulfide bond-stabilized extracellular loops. On the cytoplasmic side, a conserved amino-terminal domain is placed below VSDI, and a carboxy-terminal domain binds to the III-IV linker. The structure of NavPaS establishes an important foundation for understanding function and disease mechanism of Nav and related voltage-gated calcium channels. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395181700032 |
WOS关键词 | AMINO-ACID-RESIDUES ; C-TYPE INACTIVATION ; SWISS-MODEL ; SLOW INACTIVATION ; CRYSTAL-STRUCTURE ; GATING CHARGE ; K+ CHANNEL ; MOLECULAR DETERMINANTS ; ORGANIC CATIONS ; PROTEIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195534 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Tsinghua Univ, State Key Lab Membrane Biol, Beijing 100084, Peoples R China; 2.Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Beijing 100084, Peoples R China; 3.Tsinghua Univ, Tsinghua Peking Joint Ctr Life Sci, Sch Life Sci, Beijing 100084, Peoples R China; 4.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China |
推荐引用方式 GB/T 7714 | Shen, Huaizong,Zhou, Qiang,Pan, Xiaojing,et al. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution[J]. SCIENCE,2017,355(6328). |
APA | Shen, Huaizong,Zhou, Qiang,Pan, Xiaojing,Li, Zhangqiang,Wu, Jianping,&Yan, Nieng.(2017).Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.SCIENCE,355(6328). |
MLA | Shen, Huaizong,et al."Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution".SCIENCE 355.6328(2017). |
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