Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aah6752 |
TZAP: A telomere-associated protein involved in telomere length control | |
Li, Julia Su Zhou1; Fuste, Javier Miralles2,3; Simavorian, Tatevik1; Bartocci, Cristina1; Tsai, Jill1; Karlseder, Jan2; Denchi, Eros Lazzerini1 | |
2017-02-10 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6325页码:638-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Sweden |
英文摘要 | Telomeres are found at the end of chromosomes and are important for chromosome stability. Here we describe a specific telomere-associated protein: TZAP (telomeric zinc finger-associated protein). TZAP binds preferentially to long telomeres that have a low concentration of shelterin complex, competing with the telomeric-repeat binding factors TRF1 and TRF2. When localized at telomeres, TZAP triggers a process known as telomere trimming, which results in the rapid deletion of telomeric repeats. On the basis of these results, we propose a model for telomere length regulation in mammalian cells: The reduced concentration of the shelterin complex at long telomeres results in TZAP binding and initiation of telomere trimming. Binding of TZAP to long telomeres represents the switch that triggers telomere trimming, setting the upper limit of telomere length. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393636700051 |
WOS关键词 | CIRCLES ; ARABIDOPSIS ; GENERATION ; SHELTERIN ; CHROMATIN ; MECHANISM ; REVEALS ; COMPLEX ; STATES ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195402 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA; 2.Salk Inst Biol Studies, Dept Mol & Cell Biol, La Jolla, CA 92037 USA; 3.Univ Gothenburg, Dept Med Biochem & Cell Biol, Gothenburg, Sweden |
推荐引用方式 GB/T 7714 | Li, Julia Su Zhou,Fuste, Javier Miralles,Simavorian, Tatevik,et al. TZAP: A telomere-associated protein involved in telomere length control[J]. SCIENCE,2017,355(6325):638-+. |
APA | Li, Julia Su Zhou.,Fuste, Javier Miralles.,Simavorian, Tatevik.,Bartocci, Cristina.,Tsai, Jill.,...&Denchi, Eros Lazzerini.(2017).TZAP: A telomere-associated protein involved in telomere length control.SCIENCE,355(6325),638-+. |
MLA | Li, Julia Su Zhou,et al."TZAP: A telomere-associated protein involved in telomere length control".SCIENCE 355.6325(2017):638-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论