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DOI | 10.1126/science.aai8386 |
A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline | |
Levin, B. J.1; Huang, Y. Y.1; Peck, S. C.1; Wei, Y.2; Campo, A. Martinez-del1; Marks, J. A.1; Franzosa, E. A.3,4; Huttenhower, C.3,4; Balskus, E. P.1,4 | |
2017-02-10 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6325 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The human microbiome encodes vast numbers of uncharacterized enzymes, limiting our functional understanding of this community and its effects on host health and disease. By incorporating information about enzymatic chemistry into quantitative metagenomics, we determined the abundance and distribution of individual members of the glycyl radical enzyme superfamily among the microbiomes of healthy humans. We identified many uncharacterized family members, including a universally distributed enzyme that enables commensal gut microbes and human pathogens to dehydrate trans-4-hydroxy-L-proline, the product of the most abundant human posttranslational modification. This "chemically guided functional profiling" workflow can therefore use ecological context to facilitate the discovery of enzymes in microbial communities. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393636700039 |
WOS关键词 | PYRUVATE FORMATE-LYASE ; SEQUENCE SIMILARITY NETWORKS ; COMPARATIVE METAGENOMICS ; ROSEBURIA INULINIVORANS ; CLOSTRIDIUM-BUTYRICUM ; PROFILING REVEALS ; ESCHERICHIA-COLI ; P-CRESOL ; GLYCEROL ; PROLINE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195400 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard Univ, Dept Chem & Chem Biol, 12 Oxford St, Cambridge, MA 02138 USA; 2.MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 3.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA; 4.Broad Inst, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Levin, B. J.,Huang, Y. Y.,Peck, S. C.,et al. A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline[J]. SCIENCE,2017,355(6325). |
APA | Levin, B. J..,Huang, Y. Y..,Peck, S. C..,Wei, Y..,Campo, A. Martinez-del.,...&Balskus, E. P..(2017).A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline.SCIENCE,355(6325). |
MLA | Levin, B. J.,et al."A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline".SCIENCE 355.6325(2017). |
条目包含的文件 | 条目无相关文件。 |
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