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DOI | 10.1126/science.aal3908 |
A switch from canonical to noncanonical autophagy shapes B cell responses | |
Martinez-Martin, Nuria1; Maldonado, Paula1; Gasparrini, Francesca1; Frederico, Bruno1; Aggarwal, Shweta1; Gaya, Mauro1,3,4; Tsui, Carlson1; Burbage, Marianne1; Keppler, Selina Jessica1; Montaner, Beatriz1; Jefferies, Harold B. J.2; Nair, Usha3,4; Zhao, Yan G.5; Domart, Marie-Charlotte6; Collinson, Lucy6; Bruckbauer, Andreas1,7; Tooze, Sharon A.2; Batista, Facundo D.1,3,4 | |
2017-02-10 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6325页码:641-647 |
文章类型 | Article |
语种 | 英语 |
国家 | England; USA; Peoples R China |
英文摘要 | Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of autophagy during viral infection. In contrast to mechanistic target of rapamycin complex 1-dependent canonical autophagy, GC B cell autophagy occurred predominantly through a noncanonical pathway. B cell stimulation was sufficient to down-regulate canonical autophagy transiently while triggering noncanonical autophagy. Genetic ablation of WD repeat domain, phosphoinositide-interacting protein 2 in B cells alone enhanced this noncanonical autophagy, resulting in changes of mitochondrial homeostasis and alterations in GC and antibody-secreting cells. Thus, B cell activation prompts a temporal switch from canonical to noncanonical autophagy that is important in controlling B cell differentiation and fate. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393636700052 |
WOS关键词 | LC3 ; DIFFERENTIATION ; MACROAUTOPHAGY ; MAINTENANCE ; ACTIVATION ; PROTEINS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195394 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Francis Crick Inst, Lymphocyte Biol Lab, 1 Midland Rd, London NW1 1AT, England; 2.Francis Crick Inst, Mol Cell Biol Autophagy Lab, 1 Midland Rd, London NW1 1AT, England; 3.MIT, Ragon Inst, Massachusetts Gen Hosp, 400 Technol Sq, Cambridge, MA 02139 USA; 4.Harvard Univ, 400 Technol Sq, Cambridge, MA 02139 USA; 5.Chinese Acad Sci, Inst Biophys, 15 Datun Rd, Beijing 100101, Peoples R China; 6.Francis Crick Inst, Electron Microscopy Unit, 1 Midland Rd, London NW1 1AT, England; 7.Imperial Coll London, FILM, Exhibit Rd, London SW7 2AZ, England |
推荐引用方式 GB/T 7714 | Martinez-Martin, Nuria,Maldonado, Paula,Gasparrini, Francesca,et al. A switch from canonical to noncanonical autophagy shapes B cell responses[J]. SCIENCE,2017,355(6325):641-647. |
APA | Martinez-Martin, Nuria.,Maldonado, Paula.,Gasparrini, Francesca.,Frederico, Bruno.,Aggarwal, Shweta.,...&Batista, Facundo D..(2017).A switch from canonical to noncanonical autophagy shapes B cell responses.SCIENCE,355(6325),641-647. |
MLA | Martinez-Martin, Nuria,et al."A switch from canonical to noncanonical autophagy shapes B cell responses".SCIENCE 355.6325(2017):641-647. |
条目包含的文件 | 条目无相关文件。 |
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