Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aah4701 |
Coupling organelle inheritance with mitosis to balance growth and differentiation | |
Asare, Amma; Levorse, John; Fuchs, Elaine | |
2017-02-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6324 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Balancing growth and differentiation is essential to tissue morphogenesis and homeostasis. How imbalances arise in disease states is poorly understood. To address this issue, we identified transcripts differentially expressed in mouse basal epidermal progenitors versus their differentiating progeny and those altered in cancers. We used an in vivo RNA interference screen to unveil candidates that altered the equilibrium between the basal proliferative layer and suprabasal differentiating layers forming the skin barrier. We found that epidermal progenitors deficient in the peroxisome-associated protein Pex11b failed to segregate peroxisomes properly and entered a mitotic delay that perturbed polarized divisions and skewed daughter fates. Together, our findings unveil a role for organelle inheritance in mitosis, spindle alignment, and the choice of daughter progenitors to differentiate or remain stem-like. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393183100037 |
WOS关键词 | PEROXISOMAL MEMBRANE-PROTEINS ; OPTOGENETIC CONTROL ; SACCHAROMYCES-CEREVISIAE ; MAMMALIAN-CELLS ; GENE-EXPRESSION ; PEX11-BETA GENE ; STEM-CELLS ; DIVISION ; PROLIFERATION ; ACTIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195362 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Rockefeller Univ, Howard Hughes Med Inst, Robin Chemers Neustein Lab Mammalian Cell Biol &, New York, NY 10065 USA |
推荐引用方式 GB/T 7714 | Asare, Amma,Levorse, John,Fuchs, Elaine. Coupling organelle inheritance with mitosis to balance growth and differentiation[J]. SCIENCE,2017,355(6324). |
APA | Asare, Amma,Levorse, John,&Fuchs, Elaine.(2017).Coupling organelle inheritance with mitosis to balance growth and differentiation.SCIENCE,355(6324). |
MLA | Asare, Amma,et al."Coupling organelle inheritance with mitosis to balance growth and differentiation".SCIENCE 355.6324(2017). |
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