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DOI | 10.1126/science.aaf6407 |
A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination | |
Rao, H. B. D. Prasada1,2; Qiao, Huanyu1,2; Bhatt, Shubhang K.2; Bailey, Logan R. J.2; Tran, Hung D.2; Bourne, Sarah L.2; Qiu, Wendy2; Deshpande, Anusha2; Sharma, Ajay N.2; Beebout, Connor J.2; Pezza, Roberto J.3; Hunter, Neil1,2,4,5 | |
2017-01-27 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6323页码:403-407 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Meiosis produces haploid gametes through a succession of chromosomal events, including pairing, synapsis, and recombination. Mechanisms that orchestrate these events remain poorly understood. We found that the SUMO ( small ubiquitin-like modifier)-modification and ubiquitin-proteasome systems regulate the major events of meiotic prophase in mouse. Interdependent localization of SUMO, ubiquitin, and proteasomes along chromosome axes was mediated largely by RNF212 and HEI10, two E3 ligases that are also essential for crossover recombination. RNF212-dependent SUMO conjugation effected a checkpointlike process that stalls recombination by rendering the turnover of a subset of recombination factors dependent on HEI10-mediated ubiquitylation. We propose that SUMO conjugation establishes a precondition for designating crossover sites via selective protein stabilization. Thus, meiotic chromosome axes are hubs for regulated proteolysis via SUMO-dependent control of the ubiquitin-proteasome system. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393172800041 |
WOS关键词 | LIGASE HEI10 ; SUMOYLATION ; PROTEINS ; MOLECULE ; MEIOSIS ; RNF212 ; ROLES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195315 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Davis, Howard Hughes Med Inst, Davis, CA 95616 USA; 2.Univ Calif Davis, Dept Microbiol & Mol Genet, Davis, CA 95616 USA; 3.Oklahoma Med Res Fdn, Cell Cycle & Canc Biol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA; 4.Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA; 5.Univ Calif Davis, Dept Cell Biol & Human Anat, Davis, CA 95616 USA |
推荐引用方式 GB/T 7714 | Rao, H. B. D. Prasada,Qiao, Huanyu,Bhatt, Shubhang K.,et al. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination[J]. SCIENCE,2017,355(6323):403-407. |
APA | Rao, H. B. D. Prasada.,Qiao, Huanyu.,Bhatt, Shubhang K..,Bailey, Logan R. J..,Tran, Hung D..,...&Hunter, Neil.(2017).A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination.SCIENCE,355(6323),403-407. |
MLA | Rao, H. B. D. Prasada,et al."A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination".SCIENCE 355.6323(2017):403-407. |
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