IgG antibodies to dengue enhanced for Fc gamma RIIIA binding determine disease severity

doi:10.1126/science.aai8128

GSTDTAP > 地球科学

DOI	10.1126/science.aai8128
	IgG antibodies to dengue enhanced for Fc gamma RIIIA binding determine disease severity
	Wang, Taia T.1,2; Sewatanon, Jaturong 3,4,5; Memoli, Matthew J.6; Wrammert, Jens 4,7; Bournazos, Stylianos 1; Bhaumik, Siddhartha Kumar 4,7; Pinsky, Benjamin A.2,8; Chokephaibulkit, Kulkanya 9; Onlamoon, Nattawat 10; Pattanapanyasat, Kovit 10; Taubenberger, Jeffery K.6; Ahmed, Rafi 3,4; Ravetch, Jeffrey V.1
	2017-01-27
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	355 期号:6323 页码:395-+
文章类型	Article
语种	英语
国家	USA; Thailand
英文摘要	Dengue virus (DENV) infection in the presence of reactive, non-neutralizing immunoglobulin G (IgG) (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, because only a fraction of infections occurring in the presence of RNNIg advance to DHF/DSS, the presence of RNNIg alone cannot account for disease severity. We discovered that DHF/DSS patients respond to infection by producing IgGs with enhanced affinity for the activating Fc receptor Fc gamma RIIIA due to afucosylated Fc glycans and IgG1 subclass. RNNIg enriched for afucosylated IgG1 triggered platelet reduction in vivo and was a significant risk factor for thrombocytopenia. Thus, therapeutics and vaccines restricting production of afucosylated, IgG1 RNNIg during infection may prevent ADE of DENV disease.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000393172800039
WOS关键词	VIRUS-INFECTION ; HEMORRHAGIC-FEVER ; DEPENDENT ENHANCEMENT ; IN-VITRO ; CORRELATE ; RECEPTOR ; SEROTYPE ; PATHOGENESIS ; POLYMORPHISM ; MACROPHAGES
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/195307
专题	地球科学资源环境科学气候变化
作者单位	1.Rockefeller Univ, Lab Mol Genet & Immunol, 1230 York Ave, New York, NY 10065 USA; 2.Stanford Univ, Sch Med, Dept Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA; 3.Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA; 4.Emory Univ, Emory Vaccine Ctr, Sch Med, Atlanta, GA 30322 USA; 5.Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand; 6.Natl Inst Hlth, Natl Inst Allergy & Infect Dis, Infect Dis Lab, Viral Pathogenesis & Evolut Sect, Bethesda, MD USA; 7.Emory Univ, Sch Med, Dept Pediat, Div Infect Dis, Atlanta, GA 30322 USA; 8.Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA; 9.Mahidol Univ, Siriraj Hosp, Fac Med, Dept Paediat, Bangkok 10700, Thailand; 10.Mahidol Univ, Siriraj Hosp, Fac Med, Dept Res & Dev, Bangkok 10700, Thailand
推荐引用方式 GB/T 7714	Wang, Taia T.,Sewatanon, Jaturong,Memoli, Matthew J.,et al. IgG antibodies to dengue enhanced for Fc gamma RIIIA binding determine disease severity[J]. SCIENCE,2017,355(6323):395-+.
APA	Wang, Taia T..,Sewatanon, Jaturong.,Memoli, Matthew J..,Wrammert, Jens.,Bournazos, Stylianos.,...&Ravetch, Jeffrey V..(2017).IgG antibodies to dengue enhanced for Fc gamma RIIIA binding determine disease severity.SCIENCE,355(6323),395-+.
MLA	Wang, Taia T.,et al."IgG antibodies to dengue enhanced for Fc gamma RIIIA binding determine disease severity".SCIENCE 355.6323(2017):395-+.