Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aah6130 |
Mechanistic basis for a molecular triage reaction | |
Shao, Sichen1,2; Rodrigo-Brenni, Monica C.1,3; Kivlen, Maryann H.1; Hegde, Ramanujan S.1 | |
2017-01-20 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6322页码:298-302 |
文章类型 | Article |
语种 | 英语 |
国家 | England; USA |
英文摘要 | Newly synthesized proteins are triaged between biosynthesis and degradation to maintain cellular homeostasis, but the decision-making mechanisms are unclear. We reconstituted the core reactions for membrane targeting and ubiquitination of nascent tail-anchored membrane proteins to understand how their fate is determined. The central six-component triage system is divided into an uncommitted client-SGTA complex, a self-sufficient targeting module, and an embedded but self-sufficient quality control module. Client-SGTA engagement of the targeting module induces rapid, private, and committed client transfer to TRC40 for successful biosynthesis. Commitment to ubiquitination is dictated primarily by comparatively slower client dissociation from SGTA and nonprivate capture by the BAG6 subunit of the quality control module. Our results provide a paradigm for how priority and time are encoded within a multichaperone triage system. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000392204800040 |
WOS关键词 | RETICULUM-ASSOCIATED DEGRADATION ; MEMBRANE-PROTEIN INSERTION ; CYTOSOLIC QUALITY-CONTROL ; TAIL-ANCHORED PROTEINS ; ENDOPLASMIC-RETICULUM ; MISLOCALIZED PROTEINS ; TARGETING FACTOR ; ER MEMBRANE ; COMPLEX ; DOMAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195263 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MRC, Mol Biol Lab, Francis Crick Ave,Cambridge Biomed Campus, Cambridge CB2 0QH, England; 2.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA; 3.Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England |
推荐引用方式 GB/T 7714 | Shao, Sichen,Rodrigo-Brenni, Monica C.,Kivlen, Maryann H.,et al. Mechanistic basis for a molecular triage reaction[J]. SCIENCE,2017,355(6322):298-302. |
APA | Shao, Sichen,Rodrigo-Brenni, Monica C.,Kivlen, Maryann H.,&Hegde, Ramanujan S..(2017).Mechanistic basis for a molecular triage reaction.SCIENCE,355(6322),298-302. |
MLA | Shao, Sichen,et al."Mechanistic basis for a molecular triage reaction".SCIENCE 355.6322(2017):298-302. |
条目包含的文件 | 条目无相关文件。 |
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