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DOI | 10.1126/science.aal2541 |
The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling | |
Stegmann, Martin1; Monaghan, Jacqueline1,4; Smakowska-Luzan, Elwira2; Rovenich, Hanna1,5; Lehner, Anita3; Holton, Nicholas1; Belkhadir, Youssef2; Zipfel, Cyril1 | |
2017-01-20 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6322页码:287-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Austria; Canada; Netherlands |
英文摘要 | In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold that modulates receptor kinase complex assembly. A similar scaffolding mechanism may underlie FER function in other signaling pathways. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000392204800037 |
WOS关键词 | PEPTIDE-HORMONE ; ARABIDOPSIS ; REVEAL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195256 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Sainsbury Lab, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England; 2.Austrian Acad Sci, GMI, Vienna Bioctr VBC, A-1030 Vienna, Austria; 3.VBCF, Prot Technol Facil, Vienna, Austria; 4.Queens Univ, Dept Biol, Kingston, ON K7L 3N6, Canada; 5.Wageningen Univ, Lab Phytopathol, NL-6708 PB Wageningen, Netherlands |
推荐引用方式 GB/T 7714 | Stegmann, Martin,Monaghan, Jacqueline,Smakowska-Luzan, Elwira,et al. The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling[J]. SCIENCE,2017,355(6322):287-+. |
APA | Stegmann, Martin.,Monaghan, Jacqueline.,Smakowska-Luzan, Elwira.,Rovenich, Hanna.,Lehner, Anita.,...&Zipfel, Cyril.(2017).The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling.SCIENCE,355(6322),287-+. |
MLA | Stegmann, Martin,et al."The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling".SCIENCE 355.6322(2017):287-+. |
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