GSTDTAP  > 地球科学
DOI10.1126/science.aag0804
Industrial biomanufacturing: The future of chemical production
Clomburg, James M.1; Crumbley, Anna M.1; Gonzalez, Ramon1,2
2017-01-06
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2017
卷号355期号:6320
文章类型Review
语种英语
国家USA
英文摘要

The current model for industrial chemical manufacturing employs large-scale megafacilities that benefit from economies of unit scale. However, this strategy faces environmental, geographical, political, and economic challenges associated with energy and manufacturing demands. We review how exploiting biological processes for manufacturing (i.e., industrial biomanufacturing) addresses these concerns while also supporting and benefiting from economies of unit number. Key to this approach is the inherent small scale and capital efficiency of bioprocesses and the ability of engineered biocatalysts to produce designer products at high carbon and energy efficiency with adjustable output, at high selectivity, and under mild process conditions. The biological conversion of single-carbon compounds represents a test bed to establish this paradigm, enabling rapid, mobile, and widespread deployment, access to remote and distributed resources, and adaptation to new and changing markets.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000391739900001
WOS关键词METHANOTROPH METHYLOMICROBIUM-BURYATENSE ; METHYLOSINUS-TRICHOSPORIUM OB3B ; COENZYME M REDUCTASE ; CRISPR-CAS SYSTEMS ; CARBON-DIOXIDE ; CLOSTRIDIUM-LJUNGDAHLII ; BIOSYNTHETIC-PATHWAY ; SACCHAROMYCES-CEREVISIAE ; ENERGY-CONSERVATION ; GAS FERMENTATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/195165
专题地球科学
资源环境科学
气候变化
作者单位1.Rice Univ, Dept Chem & Biomol Engn, Houston, TX 77005 USA;
2.Rice Univ, Dept Bioengn, Houston, TX USA
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GB/T 7714
Clomburg, James M.,Crumbley, Anna M.,Gonzalez, Ramon. Industrial biomanufacturing: The future of chemical production[J]. SCIENCE,2017,355(6320).
APA Clomburg, James M.,Crumbley, Anna M.,&Gonzalez, Ramon.(2017).Industrial biomanufacturing: The future of chemical production.SCIENCE,355(6320).
MLA Clomburg, James M.,et al."Industrial biomanufacturing: The future of chemical production".SCIENCE 355.6320(2017).
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