Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4913 |
Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China | |
Vermeulen, Roel1; Downward, George S.1; Zhang, Jinming2; Hu, Wei2; Portengen, Lutzen1; Bassig, Bryan A.2; Hammond, S. Katharine3; Wong, Jason Y. Y.2; Li, Jihua4; Reiss, Boris5; He, Jun4; Tian, Linwei6; Yang, Kaiyun7; Seow, Wei Jie8,9,10; Xu, Jun11; Anderson, Kim12; Ji, Bu-Tian2; Silverman, Debra2; Chanock, Stephen2; Huang, Yunchao7; Rothman, Nathaniel2; Lan, Qing2 | |
2019-09-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:9 |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands; USA; Peoples R China; Singapore |
英文摘要 | BACKGROUND: Lung cancer rates among never-smoking women in Xuanwei and Fuyuan in China are among the highest in the world and have been attributed to the domestic use of smoky (bituminous) coal for heating and cooking. However, the key components of coal that drive lung cancer risk have not been identified. OBJECTIVES: We aimed to investigate the relationship between lifelong exposure to the constituents of smoky coal (and other fuel types) and lung cancer. METHODS: Using a population-based case-control study of lung cancer among 1,015 never-smoking female cases and 485 controls, we examined the association between exposure to 43 household air pollutants and lung cancer. Pollutant predictions were derived from a comprehensive exposure assessment study, which included methylated polycyclic aromatic hydrocarbons (PAHs), which have never been directly evaluated in an epidemiological study of any cancer. Hierarchical clustering and penalized regression were applied in order to address high colinearity in exposure variables. RESULTS: The strongest association with lung cancer was for a cluster of 25 PAHs [odds ratio (OR): 2.21; 95% confidence interval (CI): 1.67, 2.87 per 1 standard deviation (SD) change], within which 5-methylchrysene (5-MC), a mutagenic and carcinogenic PAH, had the highest individual observed OR (5.42; 95% CI: 0.94, 27.5). A positive association with nitrogen dioxide (NO2) was also observed (OR: 2.06; 95% CI: 1.19, 3.49). By contrast, neither benzo(a)pyrene (BaP) nor fine particulate matter with aerodynamic diameter <= 2.5 mu m (PM2.5) were associated with lung cancer in the multipollutant models. CONCLUSIONS: To our knowledge, this is the first study to comprehensively evaluate the association between lung cancer and household air pollution (HAP) constituents estimated over the entire life course. Given the global ubiquity of coal use domestically for indoor cooking and heating and commercially for electric power generation, our study suggests that more extensive monitoring of coal combustion products, including methylated PAHs, may be warranted to more accurately assess health risks and develop prevention strategies from this exposure. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000488971900007 |
WOS关键词 | POLYCYCLIC AROMATIC-HYDROCARBONS ; BURNING SOLID FUELS ; COAL COMBUSTION ; NITROGEN-DIOXIDE ; EXPOSURE ; INDOOR ; WEI ; EMISSIONS ; SMOKERS ; 5-METHYLCHRYSENE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/186589 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Utrecht, Div Environm Epidemiol, Inst Risk Assessment Sci, Utrecht, Netherlands; 2.NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA; 3.Univ Calif Berkeley, Sch Publ Hlth, Environm Hlth Sci Div, Berkeley, CA 94720 USA; 4.Qujing Ctr Dis Control & Prevent, Qujing, Yunnan, Peoples R China; 5.Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Community Environm & Policy, Tucson, AZ 85721 USA; 6.Univ Hong Kong, Sch Publ Hlth, Div Epidemiol & Biostat, Hong Kong, Peoples R China; 7.Kunming Med Univ, Dept Thorac Surg, Yunnan Canc Ctr, Yunnan Canc Hosp,Affiliated Hosp 3, Kunming, Yunnan, Peoples R China; 8.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore; 9.Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore, Singapore; 10.Natl Univ Hlth Syst, Singapore, Singapore; 11.Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China; 12.Oregon State Univ, Coll Agr Sci, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA |
推荐引用方式 GB/T 7714 | Vermeulen, Roel,Downward, George S.,Zhang, Jinming,et al. Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(9). |
APA | Vermeulen, Roel.,Downward, George S..,Zhang, Jinming.,Hu, Wei.,Portengen, Lutzen.,...&Lan, Qing.(2019).Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China.ENVIRONMENTAL HEALTH PERSPECTIVES,127(9). |
MLA | Vermeulen, Roel,et al."Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China".ENVIRONMENTAL HEALTH PERSPECTIVES 127.9(2019). |
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