Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4148 |
Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project | |
Clemente, Diana B. P.1,2,3,4; Vrijheid, Martine1,3,4; Martens, Dries S.2; Bustamante, Mariona1,3,4; Chatzi, Leda5,6,7; Danileviciute, Asta8; de Castro, Montserrat1,3,4; Grazideviciene, Regina8; Gutzkow, Kristine B.9; Lepeule, Johanna10,11; Maitre, Lea1,3,4; McEachan, Rosie R. C.12; Robinson, Oliver13; Schwarze, Per E.9; Tamayo, Ibon14; Vafeiadi, Marina6; Wright, John12; Slama, Rimy10,11; Nieuwenhuijsen, Mark1,3,4; Nawrot, Tim S.2,15 | |
2019-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; Belgium; USA; Greece; Netherlands; Lithuania; Norway; France; England |
英文摘要 | BACKGROUND: Telomere length is a molecular marker of biological aging. OBJECTIVE: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age. METHODS: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) (n = 1,396), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO2), particulate matter with aerodynamic diameter <= 2.5 mu m (PM2.5), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates. RESULTS: LTL was inversely associated with prenatal and 1-y childhood NO2 and PM2.5 exposures levels. Each standard deviation (SD) increase in prenatal NO(2 )was associated with a -1.5% (95% CI: -2.8, -0.2) change in LTL. Prenatal PM 2 . 5 was nonsignificantly associated with LTL (-0.7% per SD increase; 95% CI: -2.0, 0.6). For each SD increment in 1-y childhood NO2 and PM 2 . 5 exposure, LTL shortened by -1.6% (95% CI: -2.9, -0.4) and -1.4% (95% CI: -2.9, 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL. CONCLUSION: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483734400003 |
WOS关键词 | USE REGRESSION-MODELS ; COHORT PROFILE ; MULTIPLE IMPUTATION ; PARTICULATE MATTER ; CHAINED EQUATIONS ; MORTALITY ; HEALTH ; CELL ; PREGNANCY ; RISK |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/185566 |
专题 | 资源环境科学 |
作者单位 | 1.Inst Global Hlth, ISGlobal, Barcelona, Spain; 2.Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium; 3.Univ Pompeu Fabra, Barcelona, Spain; 4.Inst Hlth Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain; 5.Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA; 6.Univ Crete, Dept Social Med, Iraklion, Greece; 7.Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands; 8.Vytauto Didziojo Univ, Dept Environm Sci, Kaunas, Lithuania; 9.Norwegian Inst Publ Hlth, Oslo, Norway; 10.INSERM, Grenoble, France; 11.Univ Grenoble Alpes, IAB, Team Environm Epidemiol Appl Reprod & Resp, Grenoble, France; 12.Bradford Royal Infirm, Bradford Inst Hlth Res, Bradford, W Yorkshire, England; 13.Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England; 14.Harvard Univ, Dept Stat, Fac Arts & Sci, Cambridge, MA 02138 USA; 15.Leuven Univ, Dept Publ Hlth & Primary Care, Unit Environm & Hlth, Leuven, Belgium |
推荐引用方式 GB/T 7714 | Clemente, Diana B. P.,Vrijheid, Martine,Martens, Dries S.,et al. Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(8). |
APA | Clemente, Diana B. P..,Vrijheid, Martine.,Martens, Dries S..,Bustamante, Mariona.,Chatzi, Leda.,...&Nawrot, Tim S..(2019).Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project.ENVIRONMENTAL HEALTH PERSPECTIVES,127(8). |
MLA | Clemente, Diana B. P.,et al."Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project".ENVIRONMENTAL HEALTH PERSPECTIVES 127.8(2019). |
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