GSTDTAP  > 资源环境科学
DOI10.1289/EHP4858
Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth
Ferguson, Kelly K.1,2; van den Dries, Michiel A.2,3; Gaillard, Romy2,4; Pronk, Anjoeka5; Spaan, Suzanne5; Nemeier, Henning3,6; Jaddoe, Vincent W. V.2,4,7
2019-08-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2019
卷号127期号:8
文章类型Article
语种英语
国家USA; Netherlands
英文摘要

BACKGROUND: Perturbations in fetal growth may have adverse consequences for childhood and later life health. Organophosphate pesticide (OP) exposure has been associated with reduced birth weight at delivery but results are not consistent. We investigated this question by utilizing ultrasound measures of size in utero in combination with measures from delivery.


METHODS: Within Generation R, a population-based prospective cohort conducted between 2002 and 2006 in Rotterdam. Netherlands, we measured dialkyl phosphates (DAPs), OP metabolites, in urine samples from early, middle, and late pregnancy and created a subject-specific average to estimate OP exposure (n =784). Ultrasound measures of head circumference, femur length, and estimated fetal weight from middle and late pregnancy and delivery measures were converted to standard deviation scores (SDS). Associations with DAP average were examined in linear mixed effects models that included an interaction term between gestational age at measurement and DAP average to investigate whether the relationship differed over time. Windows of vulnerability to exposure were assessed by modeling urinary DAPs from each visit in relation to growth measurements.


RESULTS: A 10-fold increase in average DAPs was associated with a -0.53 SDS decrease in fetal length (95% CI = - 0.83, -0.23) and a -0.32 SDS decrease in estimated fetal weight (95% CI = - 0.59. -0.04) at 20 weeks of gestation. These differences corresponded to 5% and 6% decreases relative to the mean. Effect estimates were greatest in magnitude for DAP concentrations measured early in pregnancy. Associations between average DAPs and growth measures at delivery were positive but not significant for head circumference and length and were null for weight.


CONCLUSIONS: Maternal urinary DAPs were associated with decreased fetal weight and length measured during mid-pregnancy, but not at delivery.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000483734400007
WOS关键词PRENATAL EXPOSURE ; BIRTH OUTCOMES ; BISPHENOL-A ; URINARY CONCENTRATIONS ; DIALKYL PHOSPHATES ; GENERATION R ; COHORT ; CHLORPYRIFOS ; DETERMINANTS ; METABOLITES
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/185562
专题资源环境科学
作者单位1.NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA;
2.Erasmus Univ, Generat R Study Grp, Med Ctr MC Erasmus MC, Rotterdam, Netherlands;
3.Erasmus MC, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands;
4.Erasmus MC, Dept Pediat, Rotterdam, Netherlands;
5.Netherlands Org Appl Sci Res TNO, Dept Risk Anal Prod Dev, Zeist, Netherlands;
6.Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA;
7.Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
推荐引用方式
GB/T 7714
Ferguson, Kelly K.,van den Dries, Michiel A.,Gaillard, Romy,et al. Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(8).
APA Ferguson, Kelly K..,van den Dries, Michiel A..,Gaillard, Romy.,Pronk, Anjoeka.,Spaan, Suzanne.,...&Jaddoe, Vincent W. V..(2019).Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth.ENVIRONMENTAL HEALTH PERSPECTIVES,127(8).
MLA Ferguson, Kelly K.,et al."Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth".ENVIRONMENTAL HEALTH PERSPECTIVES 127.8(2019).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ferguson, Kelly K.]的文章
[van den Dries, Michiel A.]的文章
[Gaillard, Romy]的文章
百度学术
百度学术中相似的文章
[Ferguson, Kelly K.]的文章
[van den Dries, Michiel A.]的文章
[Gaillard, Romy]的文章
必应学术
必应学术中相似的文章
[Ferguson, Kelly K.]的文章
[van den Dries, Michiel A.]的文章
[Gaillard, Romy]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。