Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4858 |
Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth | |
Ferguson, Kelly K.1,2; van den Dries, Michiel A.2,3; Gaillard, Romy2,4; Pronk, Anjoeka5; Spaan, Suzanne5; Nemeier, Henning3,6; Jaddoe, Vincent W. V.2,4,7 | |
2019-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands |
英文摘要 | BACKGROUND: Perturbations in fetal growth may have adverse consequences for childhood and later life health. Organophosphate pesticide (OP) exposure has been associated with reduced birth weight at delivery but results are not consistent. We investigated this question by utilizing ultrasound measures of size in utero in combination with measures from delivery. METHODS: Within Generation R, a population-based prospective cohort conducted between 2002 and 2006 in Rotterdam. Netherlands, we measured dialkyl phosphates (DAPs), OP metabolites, in urine samples from early, middle, and late pregnancy and created a subject-specific average to estimate OP exposure (n =784). Ultrasound measures of head circumference, femur length, and estimated fetal weight from middle and late pregnancy and delivery measures were converted to standard deviation scores (SDS). Associations with DAP average were examined in linear mixed effects models that included an interaction term between gestational age at measurement and DAP average to investigate whether the relationship differed over time. Windows of vulnerability to exposure were assessed by modeling urinary DAPs from each visit in relation to growth measurements. RESULTS: A 10-fold increase in average DAPs was associated with a -0.53 SDS decrease in fetal length (95% CI = - 0.83, -0.23) and a -0.32 SDS decrease in estimated fetal weight (95% CI = - 0.59. -0.04) at 20 weeks of gestation. These differences corresponded to 5% and 6% decreases relative to the mean. Effect estimates were greatest in magnitude for DAP concentrations measured early in pregnancy. Associations between average DAPs and growth measures at delivery were positive but not significant for head circumference and length and were null for weight. CONCLUSIONS: Maternal urinary DAPs were associated with decreased fetal weight and length measured during mid-pregnancy, but not at delivery. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483734400007 |
WOS关键词 | PRENATAL EXPOSURE ; BIRTH OUTCOMES ; BISPHENOL-A ; URINARY CONCENTRATIONS ; DIALKYL PHOSPHATES ; GENERATION R ; COHORT ; CHLORPYRIFOS ; DETERMINANTS ; METABOLITES |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/185562 |
专题 | 资源环境科学 |
作者单位 | 1.NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA; 2.Erasmus Univ, Generat R Study Grp, Med Ctr MC Erasmus MC, Rotterdam, Netherlands; 3.Erasmus MC, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands; 4.Erasmus MC, Dept Pediat, Rotterdam, Netherlands; 5.Netherlands Org Appl Sci Res TNO, Dept Risk Anal Prod Dev, Zeist, Netherlands; 6.Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA; 7.Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands |
推荐引用方式 GB/T 7714 | Ferguson, Kelly K.,van den Dries, Michiel A.,Gaillard, Romy,et al. Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(8). |
APA | Ferguson, Kelly K..,van den Dries, Michiel A..,Gaillard, Romy.,Pronk, Anjoeka.,Spaan, Suzanne.,...&Jaddoe, Vincent W. V..(2019).Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth.ENVIRONMENTAL HEALTH PERSPECTIVES,127(8). |
MLA | Ferguson, Kelly K.,et al."Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth".ENVIRONMENTAL HEALTH PERSPECTIVES 127.8(2019). |
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