Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4883 |
Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study | |
Shin, Saeha1,2; Burnett, Richard T.3; Kwong, Jeffrey C.1,2,4,5; Hystad, Perry6; van Donkelaar, Aaron7; Brook, Jeffrey R.1,8; Goldberg, Mark S.9,10; Tu, Karen5; Copes, Ray1,2; Martin, Randall, V7,11; Lia, Ying4; Kopp, Alexander4; Chen, Hong1,2,3,4 | |
2019-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; USA |
英文摘要 | BACKGROUND: Although growing evidence links air pollution to stroke incidence, less is known about the effect of air pollution on atrial fibrillation (AF), an important risk factor for stroke. OBJECTIVES: We assessed the associations between air pollution and incidence of AF and stroke. We also sought to characterize the shape of pollutant-disease relationships. METHODS: The population-based cohort comprised 5,071,956 Ontario residents, age 35-85 y and without the diagnoses of both outcomes on 1 April 2001 and was followed up until 31 March 2015. AF and stroke cases were ascertained using health administrative databases with validated algorithms. Based on annual residential postal codes, we assigned 5-y running average concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O-3) from satellite-derived data, a land-use regression model, and a fusion-based method, respectively, as well as redox-weighted averages of NO2 and O-3 (O-x) for each year. Using Cox proportional hazards models, we estimated the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of AF and stroke with each of these pollutants, adjusting for individual- and neighborhood-level variables. We used newly developed nonlinear risk models to characterize the shape of pollutant-disease relationships. RESULTS: Between 2001 and 2015, we identified 313,157 incident cases of AF and 122,545 cases of stroke. Interquartile range increments of PM2.5, NO2, O-3, and O-x were associated with increases in the incidence of AF [HRs (95% CIs): 1.03 (1.01, 1.04), 1.02 (1.01, 1.03), 1.01 (1.00, 1.02), and 1.01 (1.01, 1.02), respectively] and the incidence of stroke [HRs (95% CIs): 1.05 (1.03, 1.07), 1.04 (1.01, 1.06), 1.05 (1.03, 1.06), and 1.05 (1.04, 1.06), respectively]. Associations of similar magnitude were found in various sensitivity analyses. Furthermore, we found a near-linear association for stroke with PM2.5, whereas O-x-stoke, PM2.5-, and O-x-AF relationships exhibited sublinear shapes. CONCLUSIONS: Air pollution was associated with stroke and AF onset, even at very low concentrations. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483734400008 |
WOS关键词 | LONG-TERM EXPOSURE ; HEART-RATE-VARIABILITY ; FINE PARTICULATE MATTER ; ADMINISTRATIVE DATA ; CARDIOVASCULAR-DISEASE ; HOSPITAL ADMISSIONS ; ISCHEMIC-STROKE ; HEMORRHAGIC STROKE ; OXIDATIVE STRESS ; NITROGEN-DIOXIDE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/185561 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada; 2.Publ Hlth Ontario, Toronto, ON, Canada; 3.Hlth Canada, Environm Hlth Sci & Res Bur, Populat Studies Div, 101 Tunneys Pasture Driveway,A-L 0201A, Ottawa, ON K1A 0K9, Canada; 4.ICES, Toronto, ON, Canada; 5.Univ Toronto, Dept Family & Community Med, Toronto, ON, Canada; 6.Oregon State Univ, Coll Publ Hlth & Human Studies, Corvallis, OR 97331 USA; 7.Dalhousie Univ, Dept Phys & Atmospher Sci, Halifax, NS, Canada; 8.Environm Canada, Air Qual Res Div, Toronto, ON, Canada; 9.McGill Univ, Dept Med, Montreal, PQ, Canada; 10.McGill Univ, Ctr Outcomes Res & Evaluat, Res Inst, Hlth Ctr, Montreal, PQ, Canada; 11.Carleton Univ, Dept Hlth Sci, Ottawa, ON, Canada |
推荐引用方式 GB/T 7714 | Shin, Saeha,Burnett, Richard T.,Kwong, Jeffrey C.,et al. Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(8). |
APA | Shin, Saeha.,Burnett, Richard T..,Kwong, Jeffrey C..,Hystad, Perry.,van Donkelaar, Aaron.,...&Chen, Hong.(2019).Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study.ENVIRONMENTAL HEALTH PERSPECTIVES,127(8). |
MLA | Shin, Saeha,et al."Ambient Air Pollution and the Risk of Atrial Fibrillation and Stroke: A Population-Based Cohort Study".ENVIRONMENTAL HEALTH PERSPECTIVES 127.8(2019). |
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