Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4599 |
Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs | |
Gavrard, Veronique1,2; Lacroix, Marlene Z.3; Grandin, Flare C.1,2; Collet, Severine H.1,2; Mila, Hanna1,2; Viguie, Catherine1,2; Gely, Clemence A.1,2; Rabozzi, Blandine1,2; Bouchard, Michele4; Leandri, Roger5; Toutain, Pierre-Louis3,6; Picard-Hagen, Nicole1,2 | |
2019-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | France; Canada; England |
英文摘要 | BACKGROUND: Given its hormonal activity, bisphenol S (BPS) as a substitute for bisphenol A (BPA) could actually increase the risk of endocrine disruption if its toxicokinetic (TK) properties, namely its oral availability and systemic persistency, were higher than those of BPA. OBJECTIVES: The TK behavior of BPA and BPS was investigated by administering the two compounds by intravenous and oral routes in piglet, a known valid model for investigating oral TK. METHODS: Experiments were conducted in piglets to evaluate the kinetics of BPA, BPS, and their glucuronoconjugated metabolites in plasma and urine after intravenous administration of BPA, BPS, and BPS glucuronide (BPSG) and gavage administration of BPA and BPS. A population semi-physiologically based TK model describing the disposition of BPA and BPS and their glucuronides was built from these data to estimate the key TK parameters that drive the internal exposure to active compounds. RESULTS: The data indicated that almost all the BPS oral dose was absorbed and transported into the liver where only 41% of BPS was glucuronidated, leading to a systemic bioavailability of 57.4%. In contrast, only 77% of the oral dose of BPA was absorbed and underwent an extensive first-pass glucuronidation either in the gut (44%) or in the liver (53%), thus accounting for the low systemic bioavailability of BPA (0.50%). Due to the higher systemic availability of BPS, in comparison with BPA, and its lower plasma clearance (3.5 times lower), the oral BPS systemic exposure was on average about 250 times higher than for BPA for an equal oral molar dose of the two compounds. CONCLUSION: Given the similar digestive tracts of pigs and humans, our results suggest that replacing BPA with BPS will likely lead to increased internal exposure to an endocrine-active compound that would be of concern for human health. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481576500006 |
WOS关键词 | TANDEM MASS-SPECTROMETRY ; GLUCURONIDE BPA-G ; IN-VITRO ; ESTROGENIC ACTIVITY ; QUANTIFICATION ; ADIPOGENESIS ; HUMANS ; ANALOGS ; VIVO ; PHARMACOKINETICS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/184527 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Toulouse, INRA, INP Inst Natl Polytech Toulouse, ENVT,Toxalim, Toulouse, France; 2.Univ Toulouse, ENVT, EIP, UPS, Toulouse, France; 3.Univ Toulouse, Therapeut Innovat & Resistance INTHERES, INRA, ENVT, Toulouse, France; 4.Univ Montreal, IRSPUM, Inst Rech Sante Publ, Dept Sante Environm & Sante Travail, Montreal, PQ, Canada; 5.Toulouse Univ Hosp, EA Human Fertil Res Grp 3694, Toulouse, France; 6.Univ London, Royal Vet Coll, London, England |
推荐引用方式 GB/T 7714 | Gavrard, Veronique,Lacroix, Marlene Z.,Grandin, Flare C.,et al. Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(7). |
APA | Gavrard, Veronique.,Lacroix, Marlene Z..,Grandin, Flare C..,Collet, Severine H..,Mila, Hanna.,...&Picard-Hagen, Nicole.(2019).Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs.ENVIRONMENTAL HEALTH PERSPECTIVES,127(7). |
MLA | Gavrard, Veronique,et al."Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs".ENVIRONMENTAL HEALTH PERSPECTIVES 127.7(2019). |
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