Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4601 |
Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic | |
Gaskins, Audrey J.1,2,3,9; Fong, Kelvin C.4; Abu Awad, Yara4; Di, Qian4; Minguez-Alarcon, Lidia4; Chavarro, Jorge E.1,2,3,5; Ford, Jennifer B.4; Coull, Brent A.6; Schwartz, Joel2,3,4,5; Kloog, Itai7; Souter, Irene3,8; Hauser, Russ4,5,7; Laden, Francine2,3,4,5 | |
2019-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Israel |
英文摘要 | BACKGROUND: A few studies suggest that air pollution may decrease fertility, but prospective studies and examinations of windows of susceptibility remain unclear. OBJECTIVE: We aimed to examine the association between time-varying exposure to nitrogen dioxide (NO2), ozone (O-3). fine particulate matter <2.5 mu m (PM2.5), and black carbon (BC) on in vitro fertilization (IVF) outcomes. METHODS: We included 345 women (522 IVF cycles) for the NO2, O-3, and PM2.5 analyses and 339 women (512 IVF cycles) for the BC analysis enrolled in a prospective cohort at a Boston fertility center (2004-2015). We used validated spatiotemporal models to estimate daily residential exposure to NO2, O-3, PM2.5, and BC. Multivariable discrete time Cox proportional hazards models with four periods [ovarian stimulation (OS), oocyte retrieval to embryo transfer (ET), ET to implantation, implantation to live birth] estimated odds ratios (OR) and 95% confidence intervals (CI) of failing at IVF. Time-dependent interactions were used to identify vulnerable periods. RESULTS: An interquartile range (IQR) increase in NO2, PM2.5, and BC throughout the IVF cycle was associated with an elevated odds of failing at IVF prior to live birth (OR =1.08, 95% CI: 0.95, 1.23 for NO2; OR =1.06, 95% CI: 0.88, 1.28 for PM2.5; and OR =1.16, 95% CI: 0.96, 1.41 for BC). This relationship significantly varied across the IVF cycle such that the association with higher exposure to air pollution during OS was strongest for early IVF failures. An IQR increase in NO2, PM2.5, and BC exposure during OS was associated with 1.42 (95% CI: 1.20, 1.69), 1.26 (95% CI: 0.96, 1.67), and 1.23 (95% CI: 0.96, 1.59) times the odds of failing prior to oocyte retrieval, and 1.32 (95% CI: 1.13, 1.54), 1.27 (95% CI: 0.98, 1.65), and 1.32 (95% CI: 1.10. 1.59) times the odds of failing prior to ET. CONCLUSION: Increased exposure to traffic-related pollutants was associated with higher odds of early IVF failure. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481576500007 |
WOS关键词 | RECURRENT PREGNANCY LOSS ; DIESEL EXHAUST PARTICLES ; OXIDATIVE STRESS ; MAJOR ROADWAYS ; BLACK CARBON ; DNA-DAMAGE ; MODEL ; INFLAMMATION ; INFERTILITY ; PROXIMITY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/184526 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA; 2.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 3.Harvard Med Sch, Boston, MA 02115 USA; 4.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 5.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 6.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA; 7.Ben Gurion Univ Negev, Dept Environm Geog, Beer Sheva, Israel; 8.Massachusetts Gen Hosp, Vincent Obstet & Gynecol, Boston, MA 02114 USA; 9.Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA |
推荐引用方式 GB/T 7714 | Gaskins, Audrey J.,Fong, Kelvin C.,Abu Awad, Yara,et al. Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(7). |
APA | Gaskins, Audrey J..,Fong, Kelvin C..,Abu Awad, Yara.,Di, Qian.,Minguez-Alarcon, Lidia.,...&Laden, Francine.(2019).Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic.ENVIRONMENTAL HEALTH PERSPECTIVES,127(7). |
MLA | Gaskins, Audrey J.,et al."Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic".ENVIRONMENTAL HEALTH PERSPECTIVES 127.7(2019). |
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