Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4971 |
Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment | |
Luderer, Ulrike1; Eskenazi, Brenda2; Hauser, Russ3; Korach, Kenneth S.4; McHale, Cliona M.2; Moran, Francisco5; Rieswijk, Linda2,6; Solomon, Gina7; Udagawa, Osamu8; Zhang, Luoping2; Zlatnik, Marva9; Zeise, Lauren5; Smith, Martvn T.2 | |
2019-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands; Japan |
英文摘要 | BACKGROUND: Identification of female reproductive toxicants is currently based largely on integrated epidemiological and in vivo toxicology data and, to a lesser degree, on mechanistic data. A uniform approach to systematically search, organize, integrate, and evaluate mechanistic evidence of female reproductive toxicity from various data types is lacking. OBJECTIVE: We sought to apply a key characteristics approach similar to that pioneered for carcinogen hazard identification to female reproductive toxicant hazard identification. METHODS: A working group of international experts was convened to discuss mechanisms associated with chemical-induced female reproductive toxicity and identified 10 key characteristics of chemicals that cause female reproductive toxicity: 1) alters hormone receptor signaling; alters reproductive hormone production, secretion, or metabolism; 2) chemical or metabolite is genotoxic; 3) induces epigenetic alterations; 4) causes mitochondrial dysfunction; 5) induces oxidative stress; 6) alters immune function; 7) alters cell signal transduction; 8) alters direct cell-cell interactions; 9) alters survival, proliferation, cell death, or metabolic pathways: and 10) alters microtubules and associated structures. As proof of principle, cyclophosphamide and diethylstilbestrol (DES), for which both human and animal studies have demonstrated female reproductive toxicity, display at least 5 and 3 key characteristics, respectively. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), for which the epidemiological evidence is mixed, exhibits 5 key characteristics. DISCUSSION: Future efforts should focus on evaluating the proposed key characteristics against additional known and suspected female reproductive toxicants. Chemicals that exhibit one or more of the key characteristics could be prioritized for additional evaluation and testing. A key characteristics approach has the potential to integrate with pathway-based toxicity testing to improve prediction of female reproductive toxicity in chemicals and potentially prevent some toxicants from entering common use. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000481576500013 |
WOS关键词 | SERUM DIOXIN CONCENTRATIONS ; ESTROGEN-RECEPTOR-ALPHA ; OOCYTE CUMULUS COMPLEX ; GAP-JUNCTION PROTEINS ; BISPHENOL-A EXPOSURE ; OXIDATIVE STRESS ; GRANULOSA-CELLS ; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD ; IN-UTERO ; ENDOCRINE DISRUPTORS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/184520 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Irvine, Ctr Occupat & Environm Hlth, Irvine, CA 92617 USA; 2.Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA; 3.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 4.NIEHS, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA; 5.Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Sacramento, CA USA; 6.Maastricht Univ, Inst Data Sci, Maastricht, Netherlands; 7.Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA; 8.Natl Inst Environm Studies, Ctr Hlth & Environm Risk Res, Tsukuba, Ibaraki, Japan; 9.Univ Calif San Francisco, Dept Obstet & Gynecol, San Francisco, CA 94143 USA |
推荐引用方式 GB/T 7714 | Luderer, Ulrike,Eskenazi, Brenda,Hauser, Russ,et al. Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(7). |
APA | Luderer, Ulrike.,Eskenazi, Brenda.,Hauser, Russ.,Korach, Kenneth S..,McHale, Cliona M..,...&Smith, Martvn T..(2019).Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment.ENVIRONMENTAL HEALTH PERSPECTIVES,127(7). |
MLA | Luderer, Ulrike,et al."Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment".ENVIRONMENTAL HEALTH PERSPECTIVES 127.7(2019). |
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