Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP5045 |
Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments | |
Arzuaga, Xabier1; Smith, Martyn T.2; Gibbons, Catherine F.1; Skakkelmek, Niels E.3; Yost, Erin E.4; Beverly, Brandiese E. J.5; Hotchkiss, Andrew K.4; Hauser, Russ6; Pagani, Rodrigo L.7; Schrader, Steven M.8; Zeise, Lauren9; Prins, Gail S.7,10 | |
2019-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark |
英文摘要 | BACKGROUND: Assessing chemicals for their potential to cause male reproductive toxicity involves the evaluation of evidence obtained from experimental, epidemiological, and mechanistic studies. Although mechanistic evidence plays an important role in hazard identification and evidence integration, the process of identifying, screening and analyzing mechanistic studies and outcomes is a challenging exercise due to the diversity of research models and methods and the variety of known and proposed pathways for chemical-induced toxicity. Ten key characteristics of carcinogens provide a valuable tool for organizing and assessing chemical-specific data by potential mechanisms for cancer-causing agents. However, such an approach has not yet been developed for noncancer adverse outcomes. OBJECTIVES: The objective in this study was to identify a set of key characteristics that are frequently exhibited by exogenous agents that cause male reproductive toxicity and that could be applied for identifying, organizing, and summarizing mechanistic evidence related to this outcome. DISCUSSION: The identification of eight key characteristics of male reproductive toxicants was based on a survey of known male reproductive toxicants and established mechanisms and pathways of toxicity. The eight key characteristics can provide a basis for the systematic, transparent, and objective organization of mechanistic evidence relevant to chemical-induced effects on the male reproductive system. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474528700013 |
WOS关键词 | ENDOCRINE-DISRUPTING CHEMICALS ; MALE-INFERTILITY ; SERTOLI-CELL ; OXIDATIVE STRESS ; MALE-FERTILITY ; GERM-CELLS ; IN-VITRO ; EXPOSURE ; CADMIUM ; TESTIS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/183718 |
专题 | 资源环境科学 |
作者单位 | 1.US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA; 2.Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA; 3.Univ Copenhagen, Rigshosp, Dept Growth & Reprod, Copenhagen, Denmark; 4.US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA; 5.NIEHS, Off Hlth Assessment & Translat, Natl Toxicol Program, NIH,Dept Hlth & Luman Serv, POB 12233, Res Triangle Pk, NC 27709 USA; 6.Harvard TH Chan Sch Publ Hlth, Boston, MA USA; 7.Univ Illinois, Dept Urol, Chicago, IL 60612 USA; 8.Natl Inst Occupat Safety & Hlth, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA; 9.Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Sacramento, CA USA; 10.Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA |
推荐引用方式 GB/T 7714 | Arzuaga, Xabier,Smith, Martyn T.,Gibbons, Catherine F.,et al. Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(6). |
APA | Arzuaga, Xabier.,Smith, Martyn T..,Gibbons, Catherine F..,Skakkelmek, Niels E..,Yost, Erin E..,...&Prins, Gail S..(2019).Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments.ENVIRONMENTAL HEALTH PERSPECTIVES,127(6). |
MLA | Arzuaga, Xabier,et al."Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments".ENVIRONMENTAL HEALTH PERSPECTIVES 127.6(2019). |
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