GSTDTAP  > 资源环境科学
DOI10.1289/EHP5045
Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments
Arzuaga, Xabier1; Smith, Martyn T.2; Gibbons, Catherine F.1; Skakkelmek, Niels E.3; Yost, Erin E.4; Beverly, Brandiese E. J.5; Hotchkiss, Andrew K.4; Hauser, Russ6; Pagani, Rodrigo L.7; Schrader, Steven M.8; Zeise, Lauren9; Prins, Gail S.7,10
2019-06-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2019
卷号127期号:6
文章类型Article
语种英语
国家USA; Denmark
英文摘要

BACKGROUND: Assessing chemicals for their potential to cause male reproductive toxicity involves the evaluation of evidence obtained from experimental, epidemiological, and mechanistic studies. Although mechanistic evidence plays an important role in hazard identification and evidence integration, the process of identifying, screening and analyzing mechanistic studies and outcomes is a challenging exercise due to the diversity of research models and methods and the variety of known and proposed pathways for chemical-induced toxicity. Ten key characteristics of carcinogens provide a valuable tool for organizing and assessing chemical-specific data by potential mechanisms for cancer-causing agents. However, such an approach has not yet been developed for noncancer adverse outcomes.


OBJECTIVES: The objective in this study was to identify a set of key characteristics that are frequently exhibited by exogenous agents that cause male reproductive toxicity and that could be applied for identifying, organizing, and summarizing mechanistic evidence related to this outcome.


DISCUSSION: The identification of eight key characteristics of male reproductive toxicants was based on a survey of known male reproductive toxicants and established mechanisms and pathways of toxicity. The eight key characteristics can provide a basis for the systematic, transparent, and objective organization of mechanistic evidence relevant to chemical-induced effects on the male reproductive system.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000474528700013
WOS关键词ENDOCRINE-DISRUPTING CHEMICALS ; MALE-INFERTILITY ; SERTOLI-CELL ; OXIDATIVE STRESS ; MALE-FERTILITY ; GERM-CELLS ; IN-VITRO ; EXPOSURE ; CADMIUM ; TESTIS
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/183718
专题资源环境科学
作者单位1.US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA;
2.Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA;
3.Univ Copenhagen, Rigshosp, Dept Growth & Reprod, Copenhagen, Denmark;
4.US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA;
5.NIEHS, Off Hlth Assessment & Translat, Natl Toxicol Program, NIH,Dept Hlth & Luman Serv, POB 12233, Res Triangle Pk, NC 27709 USA;
6.Harvard TH Chan Sch Publ Hlth, Boston, MA USA;
7.Univ Illinois, Dept Urol, Chicago, IL 60612 USA;
8.Natl Inst Occupat Safety & Hlth, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA;
9.Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Sacramento, CA USA;
10.Univ Illinois, Sch Publ Hlth, Chicago, IL 60612 USA
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GB/T 7714
Arzuaga, Xabier,Smith, Martyn T.,Gibbons, Catherine F.,et al. Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(6).
APA Arzuaga, Xabier.,Smith, Martyn T..,Gibbons, Catherine F..,Skakkelmek, Niels E..,Yost, Erin E..,...&Prins, Gail S..(2019).Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments.ENVIRONMENTAL HEALTH PERSPECTIVES,127(6).
MLA Arzuaga, Xabier,et al."Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments".ENVIRONMENTAL HEALTH PERSPECTIVES 127.6(2019).
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