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DOI | 10.1289/EHP3469 |
Endotoxin and (1 -> 3)-beta-D-Glucan Contamination in Electronic Cigarette Products Sold in the United States | |
Lee, Mi-Sun1; Allen, Joseph G.2; Christiani, David C.1,3 | |
2019-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Cigarette smoke contains microbes and microbial toxins, such as endotoxin and (1 -> 3)-beta-D-glucan, that may have adverse respiratory effects. To our knowledge, the potential for contamination of electronic cigarette (EC) products sold in the United States has not been investigated. OBJECTIVES: We aimed to determine whether popular cartridge and e-liquid EC products were contaminated with endotoxin or glucan and to examine differences according to the type and flavor of products. METHODS: We selected 37 cartridges and 38 e-liquid products with the highest nicotine content from the ten top-selling U.S. brands. Flavors were classified into four groups: tobacco, menthol, fruit, and other. Endotoxin and glucan were measured using an endotoxin-specific kinetic turoidimetric assay and a Glucatell (R) Kinetic Assay (Associates of Cape Cod, Inc.), respectively. RESULTS: Endotoxin concentrations were over the limit of detection (LOD) in 17 of 75 products tested (23%), and glucan concentrations were greater than LOD in 61 of 75 products (81%). After adjusting for brand and flavor, the mean glucan concentration was 3.2 times higher [95% confidence interval (CI): -0.1, 18.4] in cartridge vs. c-liquid samples. After adjusting for brand and type of product, glucan concentrations in tobacco- and menthol-flavored ECs were 10.4 (95% CI: 1.8, 44.9) and 3.5 (95% CI: 0.1, 17.3) times higher than concentrations found in fruit-flavored products. CONCLUSIONS: EC products may be contaminated with microbial toxins. Further studies with large representative samples of products are needed to confirm our findings, identify sources and routes of contamination, and evaluate health effects associated with the use of contaminated products. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000467131100002 |
WOS关键词 | HIGH-SCHOOL-STUDENTS ; TOBACCO PRODUCT ; HOUSE-DUST ; FLAVORING CHEMICALS ; EXPOSURE ; BACTERIAL ; HEALTH ; ASTHMA ; LUNG ; AIR |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/182028 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Environm & Occupat Med & Epidemiol Program, 665 Huntington Ave,Bldg 1 Room 1401, Boston, MA 02115 USA; 2.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA; 3.Harvard Med Sch, Dept Med, Div Pulm & Crit Care Med, Massachusetts Gen Hosp, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Lee, Mi-Sun,Allen, Joseph G.,Christiani, David C.. Endotoxin and (1 -> 3)-beta-D-Glucan Contamination in Electronic Cigarette Products Sold in the United States[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(4). |
APA | Lee, Mi-Sun,Allen, Joseph G.,&Christiani, David C..(2019).Endotoxin and (1 -> 3)-beta-D-Glucan Contamination in Electronic Cigarette Products Sold in the United States.ENVIRONMENTAL HEALTH PERSPECTIVES,127(4). |
MLA | Lee, Mi-Sun,et al."Endotoxin and (1 -> 3)-beta-D-Glucan Contamination in Electronic Cigarette Products Sold in the United States".ENVIRONMENTAL HEALTH PERSPECTIVES 127.4(2019). |
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