Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP3971 |
Influence of the Urban Exposome on Birth Weight | |
Nieuwenhuijsen, Mark J.1,2,3; Agier, Lydiane4; Basagana, Xavier1,2,3; Urquiza, Jose1,2,3; Tamayo-Uria, Ibon5; Giorgis-Allemand, Lise4; Robinson, Oliver6; Siroux, Valerie4; Maitre, Lea1,2,3; de Castro, Montserrat1,2,3; Valentin, Antonia1,2,3; Donaire, David1,2,3; Dadvand, Payam1,2,3; Aasvang, Gunn Marit7; Krog, Norun Hjertager7; Schwarze, Per E.7; Chatzi, Leda6,8,9,10; Grazuleviciene, Regina11; Andrusaityte, Sandra11; Dedele, Audrius11; McEachan, Rosie12; Wright, John12; West, Jane12; Ibarluzea, Jesus3,13,14,15; Ballester, Ferran2,3,16,17; Vrijheid, Martine1,2,3; Slama, Remy4 | |
2019-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain; France; USA; England; Norway; Greece; Netherlands; Lithuania |
英文摘要 | BACKGROUND: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life. OBJECTIVE: We evaluated the association of the urban exposome with birth weight. METHODS: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures. RESULTS: The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis. CONCLUSION: This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000467131100006 |
WOS关键词 | AMBIENT AIR-POLLUTION ; USE REGRESSION-MODELS ; COHORT PROFILE ; LAND-USE ; RESIDENTIAL GREENNESS ; WIDE ASSOCIATION ; PRETERM BIRTH ; CHILD COHORT ; HEALTH ; PREGNANCY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/182024 |
专题 | 资源环境科学 |
作者单位 | 1.ISGlobal Inst Global Hlth, Barcelona, Spain; 2.UPF, Barcelona, Spain; 3.CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain; 4.Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, Natl Inst Hlth & Med Res, CNRS,Inserm,IAB, Grenoble, France; 5.Harvard Univ, Dept Stat, Fac Arts & Sci, Cambridge, MA 02138 USA; 6.Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England; 7.NIPH, Oslo, Norway; 8.Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA; 9.Univ Crete, Dept Social Med, Iraklion, Greece; 10.Maastricht Univ, Fac Hlth Med & Life Sci, Dept Genet & Cell Biol, Maastricht, Netherlands; 11.Vytauto Didziojo Univ, Kaunas, Lithuania; 12.Bradford Inst Hlth Res Bradford, Bradford, W Yorkshire, England; 13.Univ Basque Country, Fac Psychol, UPV EHU, San Sebastian, Spain; 14.Hlth Res Inst, BIODONOSTIA, San Sebastian, Spain; 15.Govt Basque Country, Subdirectorate Publ Hlth Gipuzkoa, Dept Hlth, San Sebastian, Spain; 16.Univ Valencia, Nursing Sch, Valencia, Spain; 17.Univ Valencia, Joint Res Unit Epidemiol & Environm Hlth, Univ Jaume 1, FISABIO, Valencia, Spain |
推荐引用方式 GB/T 7714 | Nieuwenhuijsen, Mark J.,Agier, Lydiane,Basagana, Xavier,et al. Influence of the Urban Exposome on Birth Weight[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(4). |
APA | Nieuwenhuijsen, Mark J..,Agier, Lydiane.,Basagana, Xavier.,Urquiza, Jose.,Tamayo-Uria, Ibon.,...&Slama, Remy.(2019).Influence of the Urban Exposome on Birth Weight.ENVIRONMENTAL HEALTH PERSPECTIVES,127(4). |
MLA | Nieuwenhuijsen, Mark J.,et al."Influence of the Urban Exposome on Birth Weight".ENVIRONMENTAL HEALTH PERSPECTIVES 127.4(2019). |
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