Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP3655 |
Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children | |
Igra, Annachiara Malin1; Vahter, Marie1; Raqib, Rubhana2; Kippler, Maria1 | |
2019-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Bangladesh |
英文摘要 | BACKGROUND: Chronic cadmium exposure has been associated with osteotoxicity in adults, but little is known concerning its effects on early growth, which has been shown to be impaired by cadmium. OBJECTIVES: Our objective was to assess the impact of early-life cadmium exposure on bone-related biomarkers and anthropometry at 9 y of age. METHODS: For 504 children in a mother-child cohort in Bangladesh, cadmium exposure was assessed by concentrations in urine (U-Cd, long-term exposure) and erythrocytes (Ery-Cd, ongoing exposure) at 9 and 4.5 y of age. and in their mothers during pregnancy. Biomarkers of bone remodeling [urinary deoxypyridinoline (DPD), urinary calcium, plasma parathyroid hormone, osteocalcin, vitamin D3, insulin-like growth factor (IGF) 1. IGF binding protein 3, thyroid stimulating hormone] were measured at 9 y of age. RESULTS: In multivariable-adjusted linear models, a doubling of concurrent ti-Cd was associated with a mean increase in osteocalcin of 2.7 ng/mL (95% CI: 0.042, 5.9) and in urinary DPD of 22 nmol/L. (95% CI: 12, 32). In a combined exposure model, a doubling of maternal Ery-Cd was associated with a mean increase in urinary DPD of 15 nmol /L. (95% CI: -0.047, 30). Stratifying the osteocalcin model by gender (P-interaction( )= 0.001), a doubling of concurrent U-Cd was associated with a mean decrease in osteocalcin of -4.3 ng/mL (95% CI: -8.5, -0.080) in boys and a mean increase of 9.4 ng/mL (95% CI: 5.4, 13) in girls. The same pattern was seen with U-Cd at 4.5 y of age (P-interaction( ) = 0.016). Children's U-Cd and Ery-Cd, concurrent and at 4.5 y of age, were inversely associated with vitamin D3. CONCLUSIONS: Childhood cadmium exposure was associated with several bone-related biomarkers and some of the associations differed by gender. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462983500005 |
WOS关键词 | ARSENIC EXPOSURE ; BLOOD ; BIRTH ; LEAD ; SUPPLEMENTATION ; OSTEOPOROSIS ; MECHANISMS ; PREGNANCY ; SELENIUM ; DENSITY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/181525 |
专题 | 资源环境科学 |
作者单位 | 1.Karolinska Inst, Inst Environm Med, Box 210, SE-17177 Stockholm, Sweden; 2.Int Ctr Diarrhoeal Dis Res, Infect Dis Div, Dhaka, Bangladesh |
推荐引用方式 GB/T 7714 | Igra, Annachiara Malin,Vahter, Marie,Raqib, Rubhana,et al. Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(3). |
APA | Igra, Annachiara Malin,Vahter, Marie,Raqib, Rubhana,&Kippler, Maria.(2019).Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children.ENVIRONMENTAL HEALTH PERSPECTIVES,127(3). |
MLA | Igra, Annachiara Malin,et al."Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children".ENVIRONMENTAL HEALTH PERSPECTIVES 127.3(2019). |
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