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DOI | 10.1289/EHP2062 |
Urine Arsenic and Arsenic Metabolites in US Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study | |
Farzan, Shohreh F.1; Howe, Caitlin G.1; Zens, Michael S.2; Palys, Thomas3; Channon, Jacqueline Y.4,5,6; Li, Zhigang7; Chen, Yu8; Karagas, Margaret R.2 | |
2017-12-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:12 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Arsenic (As) exposure has been associated with increased risk for cardiovascular disease (CVD) and with hiomarkers of potential CVD risk and inflammatory processes. However, few studies have evaluated the effects of As on such hiomarkers in U.S. populations, which are typically exposed to low to moderate As concentrations. OBJECTIVES: We investigated associations between As exposures and biomarkers relevant to inflammation, oxidative stress, and CVD risk in a subset of participants from the New Hampshire Health Study, a population with low to moderate As exposure (n =418). METHODS: Associations between toenail As, total urine As (uAs), and %ufiAs metabolites [monomethyl (%uMMA(V)), climethyl (%uDMA(V)), and inorganic (%iAs) species] and plasma biomarkers, including soluble plasma vascular and cellular adhesion molecules (VCAM-1 and ICAM-1, respectively), matrix metalloproteinase-9 (MMP-9), tumor necrosis factor a, plasminogen activator inhibitor-1 (PAT-1), and urinary oxidative stress marker 15-F-2t-isoprostane (15-E-2t-ISOP), were evaluated using linear regression models. RESULTS: Covariate-adjusted estimates of associations with a doubling of urinary As suggested an 8.8% increase in 15-E-2t-IsoP (95% CI: 3.2, 14.7), and a doubling of toenail As was associated with a 1.7% increase in VCAM-1 (95% CI: 0.2, 3.2). Additionally, a 5% increase in %uMMA was associated with a 7.9% increase in 15-F-2t-IsoP (95% CI: 2.1, 14.1), and a 5% increase in %uDMA was associated with a 2.98% decrease in 15-F-2t-IsoP [(95% CI: 6.1, 0.21); p = 0.07]. However, in contrast with expectations, a doubling of toenail As was associated with a 2.3% decrease (95% CI: -4.3, -0.3) 0.3) in MMP-9, and a 5% increase in %uMMA was associated with a 7.7% decrease (95% CI: -12.6, -2.5) in PAEL CONCLUSION: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. htips://doi.org/10.1289/EHP2062 |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000462591200003 |
WOS关键词 | CELL-ADHESION MOLECULES ; CORONARY-HEART-DISEASE ; DRINKING-WATER ; CARDIOVASCULAR-DISEASE ; METHYLATION CAPACITY ; GENE-EXPRESSION ; MYOCARDIAL-INFARCTION ; SQUAMOUS-CELL ; PLASMA-LEVELS ; SKIN-LESIONS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/181241 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA; 2.Dartmouth Coll, Dartmouth Geisel Sch Med, Dept Epidemiol, 1 Med Ctr Dr, Lebanon, NH 03756 USA; 3.Dartmouth Coll, Ctr Mol Epidemiol Dartmouth, Dartmouth Geisel Sch Med, 1 Med Ctr Dr, Lebanon, NH 03756 USA; 4.Dartmouth Coll, Dept Microbiol & Immunol, Dartmouth Geisel Sch Med, 1 Med Ctr Dr, Lebanon, NH 03756 USA; 5.Dartmouth Coll, Norris Cotton Canc Ctr, Dartmouth Geisel Sch Med, 1 Med Ctr Dr, Lebanon, NH 03756 USA; 6.Dartmouth Coll, Dartmouth Geisel Sch Med, Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, 1 Med Ctr Dr, Lebanon, NH 03756 USA; 7.Dartmouth Coll, Dept Biomed Data Sci, Dartmouth Geisel Sch Med, 1 Med Ctr Dr, Lebanon, NH 03756 USA; 8.NYU, Sch Med, Dept Populat Hlth, New York, NY USA |
推荐引用方式 GB/T 7714 | Farzan, Shohreh F.,Howe, Caitlin G.,Zens, Michael S.,et al. Urine Arsenic and Arsenic Metabolites in US Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(12). |
APA | Farzan, Shohreh F..,Howe, Caitlin G..,Zens, Michael S..,Palys, Thomas.,Channon, Jacqueline Y..,...&Karagas, Margaret R..(2017).Urine Arsenic and Arsenic Metabolites in US Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(12). |
MLA | Farzan, Shohreh F.,et al."Urine Arsenic and Arsenic Metabolites in US Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.12(2017). |
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