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DOI | 10.1016/j.ecolecon.2016.08.028 |
Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP | |
Wu, Dick1,2,3,4; Bacaj, Taulant1,2; Morishita, Wade3,4; Goswami, Debanjan3,4; Arendt, Kristin L.5; Xu, Wei1,2,6; Chen, Lu5; Malenka, Robert C.3,4; Sudhof, Thomas C.1,2 | |
2017-04-20 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 544期号:7650页码:316-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory. During the induction of NMDA-receptor-dependent LTP, Ca2+ influx stimulates recruitment of synaptic AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, thereby strengthening synapses. How Ca2+ induces the recruitment of AMPA receptors remains unclear. Here we show that, in the pyramidal neurons of the hippocampal CA1 region in mice, blocking postsynaptic expression of both synaptotagmin-1 (Syt1) and synaptotagmin-7 (Syt7), but not of either alone, abolished LTP. LTP was restored by expression of wild-type Syt7 but not of a Ca2+-binding-deficient mutant Syt7. Blocking postsynaptic expression of Syt1 and Syt7 did not impair basal synaptic transmission, reduce levels of synaptic or extrasynaptic AMPA receptors, or alter other AMPA receptor trafficking events. Moreover, expression of dominant-negative mutant Syt1 which inhibits Ca2+-dependent presynaptic vesicle exocytosis, also blocked Ca2+-dependent postsynaptic AMPA receptor exocytosis, thereby abolishing LTP. Our results suggest that postsynaptic Syt1 and Syt7 act as redundant Ca2+-sensors for Ca2+-dependent exocytosis of AMPA receptors during LTP, and thereby delineate a simple mechanism for the recruitment of AMPA receptors that mediates LTP. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399524400030 |
WOS关键词 | LONG-TERM POTENTIATION ; SYNAPTIC VESICLE EXOCYTOSIS ; CALMODULIN KINASE-II ; NEUROTRANSMITTER RELEASE ; HIPPOCAMPAL-NEURONS ; TRANSMITTER RELEASE ; COMPLEXIN CONTROLS ; GENETIC-ANALYSIS ; NMDA RECEPTORS ; CA2+ SENSOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/15409 |
专题 | 资源环境科学 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA; 3.Stanford Univ, Sch Med, Nancy Pritzker Lab, Stanford, CA 94305 USA; 4.Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA; 5.Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA; 6.UT Southwestern Med Ctr, Dept Neurosci, Dallas, TX 75235 USA |
推荐引用方式 GB/T 7714 | Wu, Dick,Bacaj, Taulant,Morishita, Wade,et al. Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP[J]. NATURE,2017,544(7650):316-+. |
APA | Wu, Dick.,Bacaj, Taulant.,Morishita, Wade.,Goswami, Debanjan.,Arendt, Kristin L..,...&Sudhof, Thomas C..(2017).Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP.NATURE,544(7650),316-+. |
MLA | Wu, Dick,et al."Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP".NATURE 544.7650(2017):316-+. |
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