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DOI | 10.1088/1748-9326/aa579d |
LACTB is a tumour suppressor that modulates lipid metabolism and cell state | |
Keckesova, Zuzana1; Donaher, Joana Liu1; De Cock, Jasmine1; Freinkman, Elizaveta1,9; Lingrell, Susanne2,3; Bachovchin, Daniel A.4,5; Bierie, Brian1; Tischler, Verena6; Noske, Aurelia6; Okondo, Marian C.5; Reinhardt, Ferenc1; Thiru, Prathapan1; Golub, Todd R.4; Vance, Jean E.2,3; Weinberg, Robert A.1,7,8 | |
2017-03-30 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 543期号:7647页码:681-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada; Switzerland |
英文摘要 | Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factors. We hypothesized that the gene expression profiles of these differentiated cells could reveal the identities of genes that may function as tumour suppressors. Here we show, using in vitro and in vivo studies in mice and humans, that the mitochondrial protein LACTB potently inhibits the proliferation of breast cancer cells. Its mechanism of action involves alteration of mitochondrial lipid metabolism and differentiation of breast cancer cells. This is achieved, at least in part, through reduction of the levels of mitochondrial phosphatidylserine decarboxylase, which is involved in the synthesis of mitochondrial phosphatidylethanolamine. These observations uncover a novel mitochondrial tumour suppressor and demonstrate a connection between mitochondrial lipid metabolism and the differentiation program of breast cancer cells, thereby revealing a previously undescribed mechanism of tumour suppression. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397619700048 |
WOS关键词 | HAMSTER OVARY CELLS ; MUTANT MOUSE MODEL ; MYOGENIC DIFFERENTIATION ; PHOSPHOLIPASE-D ; LYSOPHOSPHATIDYLETHANOLAMINE ACYLTRANSFERASE ; PHOSPHATIDYLSERINE BIOSYNTHESIS ; SACCHAROMYCES-CEREVISIAE ; CANCER-CELLS ; PROTEIN ; PHOSPHATIDYLETHANOLAMINE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/15099 |
专题 | 气候变化 |
作者单位 | 1.Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA; 2.Univ Alberta, Dept Med, Edmonton, AB T6G 2S2, Canada; 3.Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada; 4.MIT, Broad Inst, Cambridge, MA 02142 USA; 5.Mem Sloan Kettering Canc Ctr, Chem Biol Program, New York, NY 10065 USA; 6.Univ Zurich Hosp, Inst Surg Pathol, Zurich, Switzerland; 7.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 8.MIT, Ludwig Ctr Mol Oncol, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 9.Metabolon Inc, POB 110407, Res Triangle Pk, NC 27709 USA |
推荐引用方式 GB/T 7714 | Keckesova, Zuzana,Donaher, Joana Liu,De Cock, Jasmine,et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state[J]. NATURE,2017,543(7647):681-+. |
APA | Keckesova, Zuzana.,Donaher, Joana Liu.,De Cock, Jasmine.,Freinkman, Elizaveta.,Lingrell, Susanne.,...&Weinberg, Robert A..(2017).LACTB is a tumour suppressor that modulates lipid metabolism and cell state.NATURE,543(7647),681-+. |
MLA | Keckesova, Zuzana,et al."LACTB is a tumour suppressor that modulates lipid metabolism and cell state".NATURE 543.7647(2017):681-+. |
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